arXiv AI

A knowledge-guided agentic framework for mitigating patient-context ambiguity in health queries

arXiv:2608. 19875v1 Announce Type: cross Abstract: Patients often submit short, underspecified queries to healthcare chatbots that lack the patient-specific information needed to determine an appropriate response.

arXiv AI
Jun 6

Evaluating the Utility of Personal Health Records in Personalized Health AI

arXiv:2605. 18937v2 Announce Type: replace Abstract: Patient-managed Personal Health Records (PHRs) promises to empower patients to better understand their health; but information in the record is complex, potentially hindering insights.

By Rory Sayres, Kejia Chen, Ayush Jain, Matthew Thompson, Jonathan Richina, Xiang Yin, Jimmy Hu, Fan Zhang, Bob Lou, Mike Sanchez, Ines Mezerreg, Meredith Schreier, Hamsa Subramaniam, I-Ching Lee, Yugang Jia, Daniel Mcduff, Yossi Matias, Avinatan Hassidim, Dale Webster, Yun Liu, Jackie Barr, Quang Duong
arXiv AI
6d ago

A general-purpose System One decision model for clinical records

The paper introduces Clinical System One (CS1), a 4‑billion‑parameter decision model that rapidly produces typed judgments from clinical records. Trained on 12.4 million Q&A pairs from 3.6 million patients, CS1 can answer multiple questions in a single forward pass, providing probability estimates for uncertain cases. In evaluations on 963,408 held‑out patients and 21 external datasets, CS1 outperformed larger open models and, when paired with a language‑model agent, efficiently identified trial‑eligible patients with far fewer tokens.

By Andrew Zhang, Trinh T. L. Vuong, Sophia J. Wagner, Dongmin Bang, Tong Ding, Yuchang Su, Mary Cipperman, Christina S. Chen, Judith Lefkes, Ramin Kahidi, Ming Y. Lu, Caiwei Tian, Tianhao Luo, Jingnan Ma, Rowland Pettit, Long Phi Le, Faisal Mahmood
arXiv AI
Oct 2

A Multi-Agent LLM Framework for Personalized Health Checkup Interpretation and Guidance

The paper introduces a multi‑agent large language model framework that interprets personalized health checkup results by assigning distinct tasks to specialized agents and combining their outputs. Experiments on 120 Korean compound queries show that the multi‑agent approach improves overall quality scores and user preference compared to a single‑agent baseline, though it incurs higher latency and cost. The benefits are most pronounced for queries requiring personal‑record lookup.

By HyungJun Kim, Taehan Lee, Soojin Cheon
arXiv AI
Jul 14

Information-seeking failures of large language models in agentic clinical reasoning

arXiv:2607. 10275v1 Announce Type: new Abstract: Large language models achieve high scores on medical knowledge assessments, yet clinical reasoning requires actively deciding what to investigate under uncertainty.

By Krischan Braitsch, Laura K. Schmalbrock, Theresa Weltermann, Andrew F. Berdel, Isabella Miller, Kai Tran, Michael Heider, Sabrina Kraus, Florian Bassermann, Jacqueline Lammert, Sebastian Ziegelmayer, Marcus Makowski, Lisa C. Adams, Keno K. Bressem
arXiv Computation and Language
Sep 28

PIA: A Personal Intelligence Agent Turning Health Conversations into Records and Records into Understanding

PIA is a personal intelligence agent that works alongside a consumer health agent to convert health conversations into structured clinical records and to transform those records into a synthesized understanding of the user. It uses a memory system with four controls—extraction, memory, retrieval, and understanding—each supported by a health module that includes a schema, medical alias dictionary, knowledge graph, and temporal rules. The agent demonstrates that deeper memory injection—from simple recall to a health snapshot to a causal trajectory—yields progressively richer answers, while also revealing challenges such as missing self‑reported data, the influence of question phrasing, and the presence of structural noise in causal links.

By Jeonghun Yoon, Dongchan Kim, Hongyeon Yu, Young-Bum Kim, Jaegul Choo
arXiv Computation and Language
Aug 27

Retrieval-Augmented Agentic Rubric Generation for Reliable Medical Response Evaluation

The paper introduces a retrieval‑augmented multi‑agent framework that automatically generates instance‑specific evaluation rubrics for medical language models. By retrieving authoritative medical evidence, decomposing it into atomic facts, and combining these with user interaction constraints, the system produces fine‑grained criteria that outperform GPT‑4o on HealthBench and LLMEval‑Med. The generated rubrics also guide response refinement, improving medical LLM output quality by 9.2%.

By Yinzhu Chen, Abdine Maiga, Hossein A. Rahmani, Emine Yilmaz
arXiv AI
Jul 29

PatientAgentBench: A Benchmark Framework for Evaluating Patient-Facing Health AI Agents

arXiv:2607. 25485v1 Announce Type: new Abstract: Health AI is evolving from answering questions to agentic systems that converse with patients, reason about health records, and act on their behalf.

By Korosh Vatanparvar, Ashutosh Joshi, Maria Xenochristou, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Daniel Lopez-Martinez, Anchal Nema, Ramya Ganesan, Will Kimbrough, Alex Woody, Yadunandana Rao, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
arXiv AI
Sep 28

AcuityBench: Evaluating Clinical Acuity Identification and Uncertainty Alignment

AcuityBench is a new benchmark that tests whether language models can correctly identify the urgency of medical care needed from user presentations. It unifies five public datasets—user conversations, online forum posts, clinical vignettes, and patient portal messages—under a shared four-level acuity framework, providing 914 cases for evaluation. The benchmark supports both explicit four-way classification and free-form conversational responses, revealing that models vary widely in accuracy and that conversational formats reduce over-triage but increase under-triage, especially for high-acuity cases.

By Robin Linzmayer (Department of Computer Science, Columbia University, Department of Biomedical Informatics, Columbia University), Georgianna Lin (Department of Biomedical Informatics, Columbia University), Di Coneybeare (Department of Emergency Medicine, Columbia University Irving Medical Center), Jason Chu (Department of Emergency Medicine, Columbia University Irving Medical Center), Trudi Cloyd (Department of Emergency Medicine, Columbia University Irving Medical Center), Manish Garg (Department of Emergency Medicine, Columbia University Irving Medical Center), Miles Gordon (Department of Emergency Medicine, Columbia University Irving Medical Center), Elizabeth Hartofilis (Department of Emergency Medicine, Columbia University Irving Medical Center), Benjamin Hong (Department of Emergency Medicine, Columbia University Irving Medical Center), Ashraf Hussain (Department of Emergency Medicine, Columbia University Irving Medical Center), Eugene Y. Kim (Department of Emergency Medicine, Columbia University Irving Medical Center), Oluchi Iheagwara King (Department of Emergency Medicine, Columbia University Irving Medical Center), Ross McCormack (Department of Emergency Medicine, Columbia University Irving Medical Center), Erica Olsen (Department of Emergency Medicine, Columbia University Irving Medical Center), John K. Riggins Jr (Department of Emergency Medicine, Columbia University Irving Medical Center), Mustafa N. Rasheed (Department of Emergency Medicine, Columbia University Irving Medical Center), Dana L. Sacco (Department of Emergency Medicine, Columbia University Irving Medical Center), Vinay Saggar (Department of Emergency Medicine, Columbia University Irving Medical Center), Osman R. Sayan (Department of Emergency Medicine, Columbia University Irving Medical Center), Amit Shembekar (Department of Emergency Medicine, Columbia University Irving Medical Center), Janice Shin-Kim (Department of Emergency Medicine, Columbia University Irving Medical Center), Wendy W. Sun (Department of Emergency Medicine, Columbia University Irving Medical Center), Bernard P. Chang (Department of Emergency Medicine, Columbia University Irving Medical Center), David Kessler (Department of Emergency Medicine, Columbia University Irving Medical Center), No\'emie Elhadad (Department of Computer Science, Columbia University, Department of Biomedical Informatics, Columbia University)