arXiv:2608. 19875v1 Announce Type: cross Abstract: Patients often submit short, underspecified queries to healthcare chatbots that lack the patient-specific information needed to determine an appropriate response.
By Mahyar Abbasian, Saba A. Farahani, Arshia Ilaty, Hung Cao, Ramesh Jain, Amir M. Rahmani
PIA is a personal intelligence agent that works alongside a consumer health agent to convert health conversations into structured clinical records and to transform those records into a synthesized understanding of the user. It uses a memory system with four controls—extraction, memory, retrieval, and understanding—each supported by a health module that includes a schema, medical alias dictionary, knowledge graph, and temporal rules. The agent demonstrates that deeper memory injection—from simple recall to a health snapshot to a causal trajectory—yields progressively richer answers, while also revealing challenges such as missing self‑reported data, the influence of question phrasing, and the presence of structural noise in causal links.
By Jeonghun Yoon, Dongchan Kim, Hongyeon Yu, Young-Bum Kim, Jaegul Choo
WildSEEK is a new dataset of 3,000 real user information‑seeking queries, manually annotated for risk‑sensitive domains and whether the query is factoid or analytical. The accompanying evaluation framework tests LLM responses against four failure criteria—sycophantic behavior, overreliance, a default US‑centric perspective, and poor handling of vulnerable populations—finding higher failure rates for analytical queries. The authors also train classifiers on WildSEEK to analyze over 1.8 million realistic queries, revealing that more than a third are high‑risk and often analytical.
By Tanise Ceron, Joachim Baumann, Elisa Bassignana, Berat Cabuk, Dirk Hovy, Debora Nozza
The paper introduces BRIE, a continuously maintainable benchmark for evaluating large language models (LLMs) in electronic health record (EHR) information retrieval. It presents a scalable framework that automatically generates question–answer pairs from longitudinal EHR notes, validated by nineteen clinicians. The benchmark allows assessment of multiple inference strategies and highlights that state‑of‑the‑art LLMs often miss clinically important information, especially when synthesis across documents is required.
By Jordan L. Cahoon, Chloe O. Stanwyck, Sulaiman Somani, Philip Chung, Kevin R Keet, Kameron C. Black, Andrea T. Fisher, Sarita Khemani, Jerry Liu, Stephen Ma, Saloni K. Maharaj, Rita M. Pandya, Eduardo Perez-Guerrero, Priyanka Pillai, Lisa Shieh, David J. H. Wu, James Xie, James C. McAvoy, Teresa Nguyen, Jessica Tran, Lucy Yin, Bridget Lin, Alison Callahan, Jason A. Fries, Nigam H. Shah, Emily Alsentzer
The paper introduces BRIE, a scalable framework that automatically creates question–answer pairs from longitudinal electronic health record notes, validated by nineteen clinicians. It offers a continuously maintainable benchmark for evaluating large language models in clinical settings, addressing limitations of manual, costly, and quickly outdated existing benchmarks. Experiments across nine LLMs and five inference strategies reveal that even state‑of‑the‑art systems often miss clinically important information, especially for synthesis‑heavy queries.
arXiv:2601.09717v2 Announce Type: replace-cross
Abstract: Online medical consultations contain sensitive health information whose privacy implications depend not only on the entities mentioned but al...
By Yiwei Yan, Guanfeng Liu
The paper introduces a multi‑agent large language model framework that interprets personalized health checkup results by assigning distinct tasks to specialized agents and combining their outputs. Experiments on 120 Korean compound queries show that the multi‑agent approach improves overall quality scores and user preference compared to a single‑agent baseline, though it incurs higher latency and cost. The benefits are most pronounced for queries requiring personal‑record lookup.
By HyungJun Kim, Taehan Lee, Soojin Cheon
MIRA is a bilingual benchmark that evaluates whether large language models (LLMs) provide consistent medical information across different user phrasings, languages, and health literacy levels. It contains 4,320 prompts derived from 60 medically reviewed low‑risk health questions and reveals that models tend to omit key information and offer fewer concrete next steps when responding to low health‑literacy signals, a phenomenon termed Differential Information Dilution (DID). A knowledge‑guided mitigation prompt can reduce this dilution for most models, notably improving Claude and Qwen.
By Mengyu Xu, Qiaoxin Yang, Qianqian Wang, Xiwei Dai, Weiyi Wu, Chongyang Gao
arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.
By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv:2507. 02983v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) hold significant promise for transforming digital health by enabling automated medical question answering.
By Mohammad Anas Azeez, Rafiq Ali, Ebad Shabbir, Zohaib Hasan Siddiqui, Gautam Siddharth Kashyap, Jiechao Gao, Usman Naseem
arXiv:2606. 12702v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly integrated into clinical systems, making it essential to evaluate the real-world utility of these systems.
By Alyssa Unell, Miguel Fuentes, Brenna Li, Bridget Lin, Meena Jagadeesan, Sanmi Koyejo, Nigam Shah
arXiv:2608.29241v1 Announce Type: new
Abstract: Clinical voice agents are now deployed in routine care, where real patients do not wait their turn: they interrupt. These systems typically use a casca...
By Zachary Ellis, Spencer Hazel, Adam Brandt, Yajie Vera He, Ernest Lim, Jared Joselowitz