arXiv AI

AI Rater Discrimination Depends on Scoring Protocol in Complex Clinical Decision-Making

arXiv:2606. 03198v1 Announce Type: cross Abstract: Clinical AI evaluation increasingly delegates scoring to large language models (LLMs) acting as AI raters, yet their scoring behavior across evaluation conditions has not been quantitatively characterized.

arXiv AI
Jun 15

Can LLMs Accurately Score Medical Diagnoses and Clinical Reasoning?

arXiv:2604. 14892v3 Announce Type: replace-cross Abstract: Evaluating medical AI systems using expert clinician panels is costly and slow, motivating the use of large language models (LLMs) as alternative adjudicators.

By Amy Rouillard, Sitwala Mundia, Linda Camara, Ziyaad Dangor, Michael Cameron Gramanie, Ismail Kalla, Shabir A. Madhi, Kajal Morar, Marlvin T. Ncube, Haroon Saloojee, Bruce A. Bassett
arXiv Computation and Language
Aug 24

An ambiguity taxonomy for evaluating large language model performance on clinical registry abstraction: a multi-site prospective study

The study evaluates large language models (LLMs) on unprocessed electronic medical record data for clinical registry abstraction, focusing on the American College of Cardiology National Cardiovascular Data Registry. In a pilot at one academic center, the LLM identified candidate data sources for each registry question, which abstractors used to define question‑specific document sets. In a subsequent validation at a second center, the LLM answered 157 registry questions with an overall mean accuracy of 91.5%, but accuracy dropped from 96% for simple medication or event flag questions to 62% for event timing questions, reflecting increasing ambiguity and required clinical reasoning.

By James Matheson, Betsy Castillo, Andrew Y. Shin, David Scheinker
arXiv Computation and Language
Aug 27

Retrieval-Augmented Agentic Rubric Generation for Reliable Medical Response Evaluation

The paper introduces a retrieval‑augmented multi‑agent framework that automatically generates instance‑specific evaluation rubrics for medical language models. By retrieving authoritative medical evidence, decomposing it into atomic facts, and combining these with user interaction constraints, the system produces fine‑grained criteria that outperform GPT‑4o on HealthBench and LLMEval‑Med. The generated rubrics also guide response refinement, improving medical LLM output quality by 9.2%.

By Yinzhu Chen, Abdine Maiga, Hossein A. Rahmani, Emine Yilmaz
arXiv AI
Jul 28

OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries

arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.

By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv AI
2d ago

Scaling Clinical Judgment to Evaluate Medical AI

arXiv:2609.12822v2 Announce Type: replace Abstract: Blinded physician evaluation has been considered by many to be the gold standard for assessing clinical reasoning in large language models (LLMs)....

By Thomas A. Buckley, Zahir Kanjee, Peter G. Brodeur, Byron Crowe, Anthony M. Pettinato, Aashna P. Shah, Adrian D. Haimovich, Liam G. McCoy, Daniel Restrepo, Jason A. Freed, Ethan Goh, Jonathan H. Chen, Laura Zwaan, Katherine E. Goodman, Daniel J. Morgan, Raja-Elie E. Abdulnour, Adam Rodman, Arjun K. Manrai
arXiv AI
Aug 13

A corpus-specific clinical RAG system matches or outperforms newer frontier LLMs on HealthBench

arXiv:2608. 12138v1 Announce Type: cross Abstract: General-purpose large language models (LLMs) have recently been reported to match or exceed specialized clinical AI tools on medical benchmarks, but such comparisons draw on a narrow set of systems and on benchmarks developed largely in high-income settings.

By Praveen Reddy, Charuta Mandke, Suvrankar Datta, Sarah Khan, Siddharth Reddy Anthireddy, Shitij Arora, Vishal Singh
arXiv Computation and Language
Sep 10

A Patient Simulation Framework for Risk Assessment of Conversational Healthcare AI: Evaluation of an Antidepressant Decision Aid

arXiv:2602.11391v5 Announce Type: replace Abstract: Objective: This study develops and validates a patient simulation framework that aligns with the National Institute of Standards and Technology AI...

By Md Tanvir Rouf Shawon, Mohammad Sabik Irbaz, Hadeel R. A. Elyazori, Keerti Reddy Resapu, Yili Lin, Vladimir Franzuela Cardenas, K. Pierre Eklou, Farrokh Alemi, Kevin Lybarger
arXiv AI
Sep 11

Emergency Department Revisit Quality Review Screening: Exploring Human Decision-Making and Artificial Intelligence Support

The study examined how clinicians and GPT‑4 evaluate emergency department revisit pairs to determine if further assessment is needed. GPT‑4 over‑identified nearly all pairs as requiring follow‑up, while clinicians used clinical gravity and differential diagnosis factors. An algorithm using a knowledge graph populated by an LLM achieved high positive predictive value for identifying pairs that clinicians deemed warranting review.

By Jonathan A. Handler, Marlene I. Robles-Granda, Jacob E. Mefford, Jeremy S. McGarvey, Gregory S. Podolej, Colleen J. Klein, Matthew D. Dalstrom, William F. Bond