arXiv:2608. 09080v1 Announce Type: cross Abstract: Large Language Models (LLMs) have achieved strong performance in medical question answering and clinical reasoning tasks.
By Maryam Tahermazandarani, Adnan Mahmood, Fahmida Islam, Quan Z. Sheng
The paper introduces the first benchmark for evaluating confidence estimation in large language models during multi‑turn medical consultations, combining three types of medical data and an information sufficiency gradient to capture how confidence and correctness evolve as evidence accumulates. Experiments with 27 methods reveal that token‑level and consistency‑level confidence approaches are limited by medical data, and that medical reasoning must be judged on both diagnostic accuracy and information completeness. Building on these findings, the authors propose MedConf, a retrieval‑augmented, linguistically grounded self‑assessment framework that aligns patient information with supporting, missing, and contradictory relations, producing interpretable confidence estimates that outperform existing methods across multiple datasets and LLMs.
By Zhiyao Ren, Yibing Zhan, Siyuan Liang, Guozheng Ma, Baosheng Yu, Dacheng Tao
arXiv:2608. 14552v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly evaluated and used in medicine, but clinical usefulness depends on answer accuracy and whether confidence tracks evidence quality and uncertainty.
By Ahmad Nazzal
arXiv:2608.29582v1 Announce Type: cross
Abstract: Current evaluations of large language models (LLMs) primarily focus on factual knowledge retrieval, overlooking the fundamental challenge of navigati...
By Yi Yu, Bo Wang, Chong Feng, Ge Shi, Xia Liu, Ziyi Yang, Xuewen Shi
arXiv:2607. 13036v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for decision support in healthcare, but clinical evidence is often incomplete or evolving.
By Oriana Presacan, Andreea Grama, Larisa Irimin\u{a}, Alireza Nik, Jaya Ojha, Vajira Thambawita, Ciprian I. B\u{a}cil\u{a}, Bogdan Ionescu, Michael A. Riegler
arXiv:2608.17809v2 Announce Type: replace
Abstract: Humans naturally form and express beliefs in daily communication, e.g., "I think the answer is 3" or "I suppose that's right." Such beliefs inevita...
By Quang Minh Nguyen, Luis Frentzen Salim
arXiv:2606. 00467v1 Announce Type: cross Abstract: Large Language Models (LLMs) are increasingly used for zero-shot annotation and LLM-as-a-judge tasks, yet their reliability hinges on how model-internalized priors interact with user-provided instructions.
By Etienne Casanova, Rafal Kocielnik, R. Michael Alvarez
The paper investigates whether language models’ self-reported confidence is meaningful without additional training. By evaluating three training‑free signals—direct verbalization, post‑hoc probability estimates, and agreement across multiple generations—on 100 TriviaQA questions, the authors find that direct verbalization alone achieves high AUROC scores (0.956 and 0.937) for correctness prediction, while agreement-based methods perform noticeably worse. Re‑eliciting confidence for the same answers shows modest score shifts and occasional decision flips, and an audit of biography claims reveals only a small confidence gap between supported and contradicted statements.
By Lukas Meyer, Sofia Rossi, Wei Chen, Thomas Laurent, Yiming Li
arXiv:2509.19375v2 Announce Type: replace-cross
Abstract: Large language models are increasingly used for clinical text classification, where overconfident misclassifications can directly affect pati...
By Mridul Sharma, Adeetya Patel, Zaneta D' Souza, Samira Abbasgholizadeh Rahimi, Siva Reddy, Sreenath Madathil
arXiv:2607. 28677v1 Announce Type: new Abstract: LLM now pass medical licensing examinations and, in curated cases, can rival physicians at diagnostic reasoning.
By Shayndhan Sivanathan, Shravan Nageswaran, Mehdi Zadem, Ryaan Sultan, Nicolas von Mallinckrodt, Max Solovyev, Alexey Matyushkin, Sumon Sadhu, Gabriele C DeLuca, Sanjeeva Jeyaretna, James Hillis, Manoj Ramachandran, Prakash Jayakumar
arXiv:2509. 08604v5 Announce Type: replace-cross Abstract: Large Language Models (LLMs) have demonstrated significant potential in medicine, with many studies adapting them through continued pre-training or fine-tuning on medical data to enhance domain-specific accuracy and safety.
By Anran Li, Lingfei Qian, Mengmeng Du, Yu Yin, Yan Hu, Zihao Sun, Yihang Fu, Hyunjae Kim, Erica Stutz, Xuguang Ai, Qianqian Xie, Rui Zhu, Jimin Huang, Yifan Yang, Siru Liu, Yih-Chung Tham, Lucila Ohno-Machado, Hyunghoon Cho, Zhiyong Lu, Hua Xu, Qingyu Chen
The paper introduces XConf, an experiential confidence estimator that augments a language model’s current inference with a record of its past graded episodes. By recalling similar past tasks and reflecting on past outcomes, XConf generates confidence scores without accessing logits or updating weights, achieving superior discrimination and calibration across diverse benchmarks. The method demonstrates significant gains in selective prediction, improving success rates on agent tasks by up to 8.7 points.
By Caiqi Zhang, Xiaochen Zhu, Chengzu Li, Yulong Chen, Dharshan Kumaran, Nigel Collier