arXiv AI

LLM Doesn't Know What It Doesn't Know: Detecting Epistemic Blind Spots via Cross-Model Attribution Divergence on Clinical Tabular Data

arXiv:2606. 19509v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly applied to structured clinical data, yet whether they can recognize the limits of their own knowledge on such tasks remains unexplored.

arXiv Computation and Language
Sep 11

Towards Reliable Medical LLMs: Benchmarking and Enhancing Confidence Estimation of Large Language Models in Medical Consultation

The paper introduces the first benchmark for evaluating confidence estimation in large language models during multi‑turn medical consultations, combining three types of medical data and an information sufficiency gradient to capture how confidence and correctness evolve as evidence accumulates. Experiments with 27 methods reveal that token‑level and consistency‑level confidence approaches are limited by medical data, and that medical reasoning must be judged on both diagnostic accuracy and information completeness. Building on these findings, the authors propose MedConf, a retrieval‑augmented, linguistically grounded self‑assessment framework that aligns patient information with supporting, missing, and contradictory relations, producing interpretable confidence estimates that outperform existing methods across multiple datasets and LLMs.

By Zhiyao Ren, Yibing Zhan, Siyuan Liang, Guozheng Ma, Baosheng Yu, Dacheng Tao
arXiv AI
Jul 16

Ask Before You Diagnose: Safe-Psych, a Sequential Evaluation Benchmark for LLMs in Psychiatry

arXiv:2607. 13036v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for decision support in healthcare, but clinical evidence is often incomplete or evolving.

By Oriana Presacan, Andreea Grama, Larisa Irimin\u{a}, Alireza Nik, Jaya Ojha, Vajira Thambawita, Ciprian I. B\u{a}cil\u{a}, Bogdan Ionescu, Michael A. Riegler
arXiv Computation and Language
Sep 18

An Analysis of Training-Free Self-Reported Confidence in Language Models

The paper investigates whether language models’ self-reported confidence is meaningful without additional training. By evaluating three training‑free signals—direct verbalization, post‑hoc probability estimates, and agreement across multiple generations—on 100 TriviaQA questions, the authors find that direct verbalization alone achieves high AUROC scores (0.956 and 0.937) for correctness prediction, while agreement-based methods perform noticeably worse. Re‑eliciting confidence for the same answers shows modest score shifts and occasional decision flips, and an audit of biography claims reveals only a small confidence gap between supported and contradicted statements.

By Lukas Meyer, Sofia Rossi, Wei Chen, Thomas Laurent, Yiming Li
arXiv AI
Aug 3

Reasoning in Real World Clinical Care: Why Large Language Models Are Not Yet Safe for Autonomous Clinical Decision Support

arXiv:2607. 28677v1 Announce Type: new Abstract: LLM now pass medical licensing examinations and, in curated cases, can rival physicians at diagnostic reasoning.

By Shayndhan Sivanathan, Shravan Nageswaran, Mehdi Zadem, Ryaan Sultan, Nicolas von Mallinckrodt, Max Solovyev, Alexey Matyushkin, Sumon Sadhu, Gabriele C DeLuca, Sanjeeva Jeyaretna, James Hillis, Manoj Ramachandran, Prakash Jayakumar
arXiv AI
Aug 6

Memorization in Large Language Models in Medicine: Prevalence, Characteristics, and Implications

arXiv:2509. 08604v5 Announce Type: replace-cross Abstract: Large Language Models (LLMs) have demonstrated significant potential in medicine, with many studies adapting them through continued pre-training or fine-tuning on medical data to enhance domain-specific accuracy and safety.

By Anran Li, Lingfei Qian, Mengmeng Du, Yu Yin, Yan Hu, Zihao Sun, Yihang Fu, Hyunjae Kim, Erica Stutz, Xuguang Ai, Qianqian Xie, Rui Zhu, Jimin Huang, Yifan Yang, Siru Liu, Yih-Chung Tham, Lucila Ohno-Machado, Hyunghoon Cho, Zhiyong Lu, Hua Xu, Qingyu Chen
arXiv AI
Sep 17

Confidence Comes from Experience: Experiential Confidence Estimation from Reasoning to Agents

The paper introduces XConf, an experiential confidence estimator that augments a language model’s current inference with a record of its past graded episodes. By recalling similar past tasks and reflecting on past outcomes, XConf generates confidence scores without accessing logits or updating weights, achieving superior discrimination and calibration across diverse benchmarks. The method demonstrates significant gains in selective prediction, improving success rates on agent tasks by up to 8.7 points.

By Caiqi Zhang, Xiaochen Zhu, Chengzu Li, Yulong Chen, Dharshan Kumaran, Nigel Collier