The paper introduces SCR-MF, a two‑stage workflow for single‑cell RNA sequencing imputation that first detects dropout events with scRecover and then imputes missing values using the non‑parametric missForest algorithm. Benchmarking on public and simulated datasets shows that SCR‑MF delivers robust, interpretable results that match or surpass existing methods while maintaining biological fidelity. Runtime analysis indicates that SCR‑MF balances accuracy with computational efficiency, making it well suited for mid‑scale single‑cell studies.
arXiv:2601. 14653v3 Announce Type: replace Abstract: Missing data in single-cell sequencing datasets poses significant challenges for extracting meaningful biological insights.
arXiv:2609.39613v1 Announce Type: new Abstract: Missing data are a fundamental challenge in statistical analysis and machine learning, as the choice of imputation method substantially impacts downstr...
arXiv:2606. 07676v1 Announce Type: cross Abstract: Spatial transcriptomics (ST) is a powerful tool for exploring biological properties dependent on structure, proximity, and interaction in tissue.
arXiv:2607. 29043v1 Announce Type: cross Abstract: Single-cell RNA sequencing (scRNA-seq) has become an essential tool in modern cellular biology, and generating accurate synthetic scRNA-seq data is becoming increasingly important.
arXiv:2607. 07725v1 Announce Type: cross Abstract: Genomic prediction models often fail to transfer across institutions because sequencing panels differ across sites, creating structural feature missingness at deployment.
The paper introduces a pre‑training pipeline that creates transformer‑based imputation specialists for tabular data with specific missingness patterns. By featurizing entries, generating synthetic data with configurable missingness modules, and fitting on millions of synthetic tables, the pipeline produces pattern‑specific models that outperform dedicated methods for each missingness pattern. A default model trained only on MCAR data, TabImpute, remains robust across all tested patterns, and the authors release the pipeline, models, and a new benchmark of 42 datasets and 11 missingness patterns.
The paper introduces scKITE, a single-cell foundation model that incorporates biological knowledge—cell-level text annotations and gene-level regulatory information—into a shared Transformer encoder via lightweight auxiliary decoders used only during pretraining. This approach provides a new scaling dimension beyond merely increasing data size, enabling the model to achieve superior performance on diverse downstream tasks with only 179,067 pretraining samples, less than 0.5% of the data used by previous strong scFMs. The study demonstrates that knowledge-enhanced pretraining can yield significant gains while reducing computational cost.
Fed-ReMasker is a federated learning approach that adapts the ReMasker masked autoencoder for tabular data imputation, specifically addressing feature-level missingness where entire features are absent at some centers. The method enables centers to impute unobserved features by leveraging knowledge from collaborating institutions. In benchmark tests on synthetic and real-world datasets, Fed-ReMasker achieves the lowest imputation error in the majority of scenarios and remains robust to client heterogeneity, closely matching the performance of a centralized model.
arXiv:2606. 26563v1 Announce Type: cross Abstract: Single-cell studies require analysts to convert raw measurements into specific biological claims through multi-step workflows and integration of metadata, assay context, and auxiliary evidence.
arXiv:2607. 05613v1 Announce Type: new Abstract: Clinical care often relies on key laboratory indicators, yet real-world patient visits are sparse and tests are ordered irregularly, leading to pervasive missingness.
arXiv:2606. 09558v1 Announce Type: cross Abstract: Motivation: Transformer-based models are increasingly applied to large-scale single-cell transcriptomics, showing strong performance through self-supervised learning on millions of cells.
arXiv:2606. 06328v1 Announce Type: new Abstract: In healthcare, multimodal time series tasks often operate on incomplete observations in practice, for example when ECG segments are lost because electrodes detach or an entire respiratory channel is unavailable during overnight monitoring.