The growing adoption of digital pathology has rapidly expanded collections of hematoxylin-and-eosin whole-slide images, yet efficient navigation through these archives remains challenging, as metadata...
arXiv:2510.23224v2 Announce Type: replace Abstract: The rapid digitization of histopathology slides has opened new opportunities for computational tools in clinical and research workflows. Content-ba...
arXiv:2609.00396v1 Announce Type: new Abstract: Histopathological whole slide images (WSIs) are central to cancer diagnosis, but their gigapixel scale, tissue heterogeneity, weak slide-level supervis...
arXiv:2605. 24253v2 Announce Type: replace-cross Abstract: Digital pathology archives increasingly contain multiple whole-slide images (WSIs) per case, capturing spatially distinct tumour regions and reflecting intrinsic morphological heterogeneity.
WILSON is a vision–language foundation model that represents whole‑slide images and multi‑slide patient cases as single multi‑magnification composite images. Trained on about 189,000 Mayo Clinic slides covering 42 organs and 829 diagnostic entities, it outperforms dedicated case‑level models on internal cohorts and matches slide‑level models while using far less compute. Fine‑tuning on triple‑negative breast cancer data improves histologic subtyping and lymphocyte grading, and the model retrieves diagnostic text with high recall and generates captions closer to report references than prior methods.
The paper introduces Locked Image Multiple Instance PreTraining (LIMIT), a method that aligns slide‑level pathology reports with patch‑level visual features by freezing a vision encoder and fine‑tuning a text encoder. LIMIT uses report embeddings as cross‑attention queries over bags of patch features, optimizing slide representations via InfoNCE. Applying LIMIT, the authors create CONCH‑Z, which achieves state‑of‑the‑art zero‑shot performance on 22 pathology tasks, outperforming vision‑language encoders trained on curated caption datasets and narrowing the gap with larger slide‑level foundation models.
The study introduces an evidence-aware evaluation protocol for a retrieval‑augmented generation system focused on breast lesion management literature. Using an 18‑document corpus and 18 queries, the authors compared dense embeddings, BM25, and cross‑encoder reranking across various chunk sizes and overlaps, finding that a hybrid retriever with 384‑token chunks and 20% overlap achieved top‑three retrieval success for 17 of 18 queries and high recall and precision metrics. Expanding ground‑truth relevance annotations increased recognized evidence spans and accepted chunk targets, though retrieval rankings remained unchanged, underscoring the sensitivity of evaluation to annotation coverage.
arXiv:2607.19261v4 Announce Type: replace-cross Abstract: Whole-slide image (WSI) diagnosis requires identifying diagnostically relevant regions, examining them across magnifications, and integrating...
arXiv:2606. 26157v1 Announce Type: cross Abstract: The rapid growth of digital pathology has created an urgent need for efficient indexing and retrieval of whole slide images (WSIs).
Whole-slide image (WSI) diagnosis requires identifying diagnostically relevant regions, examining them across magnifications, and integrating multi-scale evidence. However, most existing pathology benchmarks evaluate models on pre-cropped patches or pre-extracted slide features, leaving their ability to acquire evidence directly from gigapixel WSIs largely untested.
Large chest radiography archives are difficult to search because most studies are paired only with free-text reports rather than structured clinical annotations. Vision-language models offer a natural interface for text-to-image retrieval, but current biomedical models are primarily optimized for report-to-image matching rather than for satisfying short clinical search queries.
The paper identifies a representational bottleneck in 3D CT embeddings that limits pathology coverage in automated radiology reports. It introduces AdaRAG-CT, an adaptive retrieval-augmented framework that supplements visual features with controlled textual retrieval to improve report generation. On the CT-RATE benchmark, AdaRAG-CT achieves state‑of‑the‑art clinical efficacy, raising Clinical F1 from 0.420 to 0.480.