arXiv:2608. 05893v1 Announce Type: new Abstract: Electrocardiography (ECG) is one of the most widely used non-invasive tools for diagnosing cardiovascular disease, but transforming multi-lead ECG recordings into reliable clinical reports remains challenging.
By Akanta Das, Tasinul Islam Ahon, Ahmed Mahir Sultan Rumi, Md Mahbubur Rahman, Tausif Amim Shadly, Tanzima Hashem
ECGQuest is a new benchmark that evaluates language models on the contextual knowledge required for electrocardiogram interpretation, featuring 10,904 True/False questions derived from 23 ECG references and 2003‑2025 Computing in Cardiology proceedings. The study tested 23 commercial and open‑source models, finding that zero‑shot accuracy ranged from 49.5% to 74.4% and that fine‑tuning with Low‑Rank Adaptation improved all open‑source models by 6.5–14.1%, with the best fine‑tuned model achieving 76.3% accuracy and a five‑model ensemble reaching 78.5%. ECGQuest demonstrates that parameter‑efficient fine‑tuning can enable smaller models to compete with larger commercial ones on ECG‑specific tasks.
By Mohammadsina Hassannia, Matthew A. Reyna, Reza Sameni
arXiv:2608. 09053v1 Announce Type: cross Abstract: Cardiologists interpret electrocardiograms by localizing waveform components, measuring rhythm and interval patterns, and translating these structured observations into diagnostic evidence.
By Hongxiang Gao, He-yang Xu, Yuwen Li, Minghui Zhao, Zhipeng Cai, Xingyao Wang, Chenxi Yang, Jianqing Li, Chengyu Liu
Cardiologists interpret electrocardiograms by localizing waveform components, measuring rhythm and interval patterns, and translating these structured observations into diagnostic evidence. Whether this expert reading process can serve as an effective prior for ECG agents remains unclear.
arXiv:2607. 20814v1 Announce Type: new Abstract: The electrocardiogram (ECG) is a cornerstone of cardiac as- sessment, yet clinical deployment of deep learning models remains con- strained by limited interpretability and the hallucination risk of large language models (LLMs).
By Hai-Nam Duy Vuong, Duy-Anh Bui, Trong-Nghia Nguyen, Kim-Ngan Thi Nguyen, Trang Mai Xuan, Tien-Cuong Nguyen, Van-Dem Pham, Thien Van Luong
arXiv:2608. 14723v1 Announce Type: cross Abstract: Reduced left ventricular ejection fraction (LVEF) is frequently asymptomatic and often detected only after advanced heart failure develops.
By Burcu Ozek, Aruna Mohan, David Vorchheimer, Daniel Weiss, Eyal Kedar, Tamar Sobol, Or Zilbershot, Fatemeh Afghah
arXiv:2607. 27404v1 Announce Type: new Abstract: Existing benchmarks for electrocardiogram foundation models primarily evaluate downstream predictive performance, providing limited insight into whether their internal representations can be faithfully decomposed, clinically interpreted, or reproduced across independent analyses.
By Yixuan Duan, Wei Qiu
A multicenter study developed an AI-enabled electrocardiography (AI-ECG) model that predicts vessel-specific hemodynamically significant stenosis using coronary computed tomographic angiography (CCTA) as the reference. The model demonstrated strong discrimination in internal and external cohorts, including normal ECGs, and produced low-, intermediate-, and high-risk strata that correlated with stenosis severity and major adverse cardiovascular events. Calibration, decision curve analyses, and integration with guideline-based pre-test probability showed clinical utility, while waveform and attribution analyses revealed physiologically meaningful ECG features linked to high-risk predictions.
By Yujie Xiao, Qinghao Zhao, Gongzheng Tang, Hao Zhang, Zhuoran Kan, Deyun Zhang, Jun Li, Guangkun Nie, Xiaocheng Fang, Haoyu Wang, Shun Huang, Tong Liu, Jian Liu, Kangyin Chen, Shenda Hong
arXiv:2605. 29977v2 Announce Type: replace-cross Abstract: High-fidelity ECG interpretation is increasingly reliant on massive foundation models, yet their deployment in clinical edge-care remains hindered by extreme computational demands.
By Dang Nguyen Hong, Nhi Ngoc-Yen Nguyen, Huy-Hieu Pham
arXiv:2606. 00123v1 Announce Type: cross Abstract: Multimodal Large Language Models (MLLMs) have shown strong performance on public medical benchmarks, yet existing evaluations often remain weak proxies for clinical use, relying on isolated inputs and simplified recognition-style tasks.
By Zixian Su, Hongkai Zhang, Fan Gao, Encheng Su, Taiping Qu, Jingwei Guo, Nan Zhang, Hui Wang, Zhen Zhou, Kairui Bo, Yan Chen, Yue Ren, Shuai Li, Lei Xu, Henggui Zhang
arXiv:2607. 24035v1 Announce Type: cross Abstract: Explainable AI (XAI) is used to assess whether artificial intelligence models rely on meaningful patterns, yet explanations that appear plausible for individual predictions may systematically misrepresent model behavior.
By Nils Gumpfer, Michael Guckert, Samuel Sossalla, Birgit A{\ss}mus, Jennifer Hannig
The study demonstrates that contrastive pre‑training of ECG representations using cardiac magnetic resonance (CMR) imaging data can enhance ECG‑based detection of Chagas disease. By aligning an ECG encoder with a CMR embedding space from 63,193 paired UK Biobank examinations, the authors achieved higher AUROC and sensitivity metrics on CODE‑15%, SaMi‑Trop, and PhysioNet/CinC 2025 Challenge datasets compared to an unaligned baseline. The approach shows that imaging‑supervised ECG representations generalize across different populations and resource‑constrained settings.
By Laura Alvarez-Florez, Daniel Uyterlinde, Samuel Ruip\'erez-Campillo, Lukas P. A. Arts, Folkert W. Asselbergs, Fleur V. Y. Tjong