Diffusion MRI enables non-invasive probing of tissue microstructure, but accurate parameter estimation is challenged by noise-related effects. In supervised machine learning frameworks trained on simulated data, discrepancies between the noise characteristics of simulated and acquired signals introduce a form of covariate shift, whereby the input signal distribution differs between training and inference.
Brain tissue microstructure estimation with machine learning provides higher computational efficiency than conventional fitting. However, machine learning still presents important limitations that hamper its clinical utility.
arXiv:2606. 18354v1 Announce Type: cross Abstract: Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation, privacy preservation, and improved model generalization.
By Muge Zhang, Muhammad Ali Khaliq, Jamal Alsakran, Byeong Kil Lee, Jeeho Ryoo
arXiv:2608.08693v2 Announce Type: replace
Abstract: Quantitative T2* maps have strong potential for biomarker discovery but are limited by long scan times, rendering them impractical in clinical sett...
By Gideon N. L. Rouwendaal, Natascha Niessen, Hannah Eichhorn, Dirk H. J. Poot, Christine Preibisch, Julia A. Schnabel
The paper introduces a synthetic training framework for segmenting long‑tail haemorrhagic lesions such as cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS) without requiring real lesion annotations. By starting from anatomical brain parcellations, the method applies spatial augmentation, voxel resampling, and procedural insertion of lesion labels guided by clinical priors, then synthesises images with randomized intensity, blurring, and Rician noise. Models trained on these synthetic image‑label pairs outperformed classical filter baselines, achieving higher AUPRC and AUROC for both cSS and CMB segmentation.
By Yuan Cao, Sumeet Dash, Antonia Zachariadis, Stefanie Schreiber, Katja Neumann, Jose Bernal
Objective: Radiomic texture features are usually computed in voxel-index neighborhoods, implicitly assuming isotropic spatial relationships. In anisotropic images, this can confound voxel geometry with interpolation-induced signal changes.
arXiv:2606. 28513v1 Announce Type: cross Abstract: Positron emission tomography (PET) seeks to balance diagnostic quality with ra-diation dose.
By Raymond Confidence, Udunna C. Anazodo
arXiv:2606. 15457v1 Announce Type: cross Abstract: 3D FLAIR MRI is widely recommended as one of the standard MRI sequences for brain imaging in multiple sclerosis (MS), but publicly available MS datasets remain relatively small and vary across scanners, acquisition protocols, and lesion patterns.
By Weidong Zhang, Yongchan Jung, Shafayat Mowla Anik, Furen Xiao, Vasudevan Janarthanan, Enkhzaya Chuluunbaatar, Byeong Kil Lee, Jeeho Ryoo
The study introduces a voxel-spacing-aware radiomic framework that incorporates physical geometry into texture computation without resampling, modifying PyRadiomics to preserve native image signals. Four extraction configurations—native non-resampled (NR), isotropic resampling (RS), voxel-spacing-aware (VS), and fake-isotropic preprocessing (FK)—were compared across 685 CT pulmonary nodules and 209 MRI breast cases, evaluating 196 radiomic descriptors. Results show that VS closely matches NR (median ICC(A,1) ≈0.998) while RS and FK exhibit lower agreement, indicating that spacing metadata alone can significantly influence radiomic features.
By David Corral Fontecha, Juan Miranda Bautista, Pablo Menendez Fern\'andez-Miranda, Sergio Rubio-Mart\'in, Lara Lloret Iglesias, Jose A. Vega
arXiv:2609.14312v1 Announce Type: new
Abstract: Multi-shell diffusion MRI (dMRI) unlocks more expressive microstructural modeling than single-shell scans, yet its longer acquisition time hinders depl...
By Binghua Li, Christina Andica, Tong Liang, Ziqing Chang, Chao Li, Wataru Uchida, Kaito Takabayashi, Qibin Zhao, Toshihisa Tanaka, Zhe Sun, Shigeki Aoki
The paper presents a systematic comparison of recurrent neural networks and Transformer models for iterative diffusion MRI tractography, focusing on training strategies, input representations, and hyperparameter tuning. It introduces a generation‑validation phase that provides streamline‑level supervision, enabling the models to achieve the best performance reported on the ISMRM2015 challenge dataset. The study also evaluates the effects of missing bundles, noisy training data, and invalid fibers, and demonstrates applicability to in‑vivo data from the Tractoinferno database.
By Emmanuelle Renauld, Philippe Poulin, Hugo Larochelle, Antoine Th\'eberge, Maxime Descoteaux
The paper introduces a 3D residual wavelet diffusion model for super‑resolving ultra low‑field MRI scans. By using a lossless wavelet reparameterisation, residual shifting, and domain randomisation, the method fits whole‑brain data on a single GPU, speeds up sampling, and generalises across scanners. It achieves volumetric accuracy comparable to leading regression approaches while producing per‑voxel uncertainty maps that reveal under‑determined regions and preserves disease‑relevant atrophy in cognitively impaired subjects.
By Rui W. Yeow, Millie Beament, Fred Dick, Raha Razin, Martina Bocchetta, David L. Thomas, Henry F. J. Tregidgo, Daniel C. Alexander, James H. Cole