arXiv AI

Guideline-grounded retrieval-augmented generation for ophthalmic clinical decision support

The paper introduces Oph‑Guid‑RAG, a multimodal retrieval‑augmented generation system tailored for ophthalmology clinical question answering. It treats each guideline page as an independent evidence unit, retrieving page images to preserve tables, flowcharts, and layout, and employs a controllable retrieval framework with routing and filtering to reduce noise. Evaluated on HealthBench, the system outperforms GPT‑5.2 and GPT‑5.4 on hard cases, achieving significant gains in overall score and accuracy, and ablation studies confirm the importance of reranking, routing, and retrieval design.

arXiv Computation and Language
Oct 23

RetiJev: Fast and Source-Grounded Ophthalmic Decision Models

RetiJev is a family of 0.8B‑9B decision models designed for ophthalmic clinical decision support, offering fast, accurate, and privacy‑preserving inference without autoregressive decoding. The authors created RetiJev‑Data, a source‑grounded corpus of 78,158 clinical‑decision and diagnosis questions, 50,074 guideline‑grading questions, and a 24,662‑question evaluation benchmark. RetiJev outperforms a 27B LLM and the commercial Jev 1.13 model on guideline grading and clinical decisions, achieving the highest accuracy while answering a case in 158 ms on a single GPU—3.5× faster than LLM generation and 470× faster than reasoning.

By Bo Liu, Lianyu Wang, Meng Wang, Ching-Yu Cheng, Huazhu Fu
arXiv AI
Sep 21

LiteMedCoT-VL: Parameter-Efficient Adaptation for Medical Visual Question Answering

LiteMedCoT-VL is a parameter‑efficient pipeline that transfers chain‑of‑thought reasoning from a 235B teacher model to a 2B student model using LoRA fine‑tuning on explanation‑enriched data. The approach enables a compact vision‑language model to perform medical visual question answering without relying on image captions, achieving 64.9% accuracy on the PMC‑VQA benchmark—an 11‑point improvement over the zero‑shot Qwen3‑VL‑4B baseline. Visual grounding analysis confirms that the model bases its predictions on image content rather than textual priors.

By Runze Ma, Shunbo Jia, Haonan Lyu, Guo Liu, Caizhi Liao
arXiv AI
Aug 19

A Multimodal Agentic Pathology Co-pilot via Evidence Grounded Reasoning

PathPocket is a multimodal AI co‑pilot that grounds pathology decision‑making in evidence. It builds the largest pathology evidence corpus (≈110,472 documents) and a hypergraph of 4.55 million entities and 7.10 million relations to support traceable reasoning. The system handles text and multimodal queries, including ROI and gigapixel whole‑slide images, and outperforms current state‑of‑the‑art models on a benchmark of over 200,000 real‑world cases, improving pathologists’ diagnostic accuracy and confidence.

By Zhe Xu, Zhengyu Zhang, Zhiyuan Cai, Jiahao Xu, Yijie Lin, Ziyi Liu, Junlin Hou, Hongyi Wang, Yuxiang Nie, Yihui Wang, Jiabo Ma, Ling Liang, Yingxue Xu, Zhengrui Guo, Guanghao Wu, Danyi Li, Ziqi Zhou, Donglin Tan, Zhijian Cen, Ying Tan, Xiaolin Liu, Qi Xie, Xiaoying Tang, Xi Peng, Cheng Deng, Lijuan Qu, Ronald Cheong Kin Chan, Li Liang, Hao Chen
arXiv AI
Jun 11

OpenMedReason: Scientific Reasoning Supervision for Medical Vision-Language Models

arXiv:2606. 12169v1 Announce Type: cross Abstract: High-stakes clinical use of large vision-language models (LVLMs) requires reasoning that is grounded in visual evidence and clinical knowledge, not just correct final answers.

By Negin Baghbanzadeh, Pritam Sarkar, Michael Colacci, Abeer Badawi, Adibvafa Fallahpour, Arash Afkanpour, Leonid Sigal, Ali Etemad, Elham Dolatabadi
arXiv Computation and Language
Sep 23

MultiViewDx: Evidence-Linked Multi-View Clinical Diagnosis

MultiViewDx is a physician‑validated multimodal instruction dataset that links medical imaging studies with patient context and normalizes heterogeneous reports into an evidence‑linked workflow (evidence → findings → differential discussion → diagnosis). The dataset covers a wide range of imaging modalities and uses a unified image‑text retriever to ensure that instruction synthesis is grounded in source‑supported evidence. Fine‑tuned models on MultiViewDx achieve the highest average accuracy on four MedVQA benchmarks and receive the strongest overall rating on JAMA Clinical Challenge cases, with ablations confirming the importance of case‑level multi‑view organization and evidence‑linked reasoning.

By Junda Wang, Zonghai Yao, Yujan Ting, Eric Z. Chen, Hieu Tran, Hong Yu, Weijing Huang, Terrence Chen
arXiv AI
Aug 12

MIRA: Medical Image Reflection for Agentic Diagnosis

arXiv:2608. 10827v1 Announce Type: cross Abstract: Medical visual agents can use tools to inspect images and retrieve external knowledge, but indiscriminate tool use may introduce noisy or misleading evidence.

By Shengzhi Wang, Jun Yang, Kai Wu, Xiaozhong Ji, Yiwen Ye, Ziyang Chen, Mingliang Xiong, Wen Fang, Mingqing Liu, Mengyuan Xu, Miaoxuan Shan, Caiyan Liu, Bin He, Qingwen Liu
arXiv AI
Jul 7

IRIS: An Intelligent Vision-Language System for Ocular Surface Diseases via Topic Tree and Scene-Driven VQA Generation

arXiv:2607. 04344v1 Announce Type: cross Abstract: While Large Vision-Language Models (VLMs) demonstrate remarkable generic capabilities, their clinical reasoning in specialized domains like ocular surface diseases (OSDs) is severely hindered by a paucity of high-fidelity, multimodal instruction-tuning data.

By Hao Wei, Wenjin Qi, Dasen Dai, Minqing Zhang, Wu Yuan