arXiv:2606. 28692v1 Announce Type: new Abstract: Treatment reasoning underpins every therapeutic decision, integrating disease context, comorbidities, medications, contraindications, and evolving biomedical knowledge to select an appropriate therapy.
By Shanghua Gao, Ayush Noori, Richard Zhu, Curtis Ginder, Zhenglun Kong, Xiaorui Su, Justin Kauffman, Benjamin S. Glicksberg, Joshua Lampert, Ankit Sakhuja, Ashwin Sawant, ATHENA-R1 Evaluation Consortium, David A. Clifton, Noa Dagan, Ran Balicer, Marinka Zitnik
The paper reviews how Large Language Models (LLMs) are being adapted for medical reasoning, moving beyond single-step answers to systems that can systematically, transparently, and verifiably reason. It introduces a taxonomy of enhancement techniques, split into training-time methods such as supervised fine‑tuning and reinforcement learning, and test-time methods like prompt engineering and multi‑agent systems. The review examines their application across text, image, and code modalities in key clinical areas—diagnosis, education, and treatment planning—and tracks the shift in evaluation benchmarks from simple accuracy to more nuanced assessments of reasoning quality and visual interpretability.
By Zizhan Ma, Wenxuan Wang, Meidan Ding, Shiyi Zheng, Shengyuan Liu, Jie Liu, Jiaming Ji, Linlin Shen, Yixuan Yuan, Wenting Chen
arXiv:2608. 05375v1 Announce Type: new Abstract: Clinical machine learning (ML) has the potential to support high-stakes medical decision-making, but reliable deployment is often constrained by scarce, heterogeneous, and temporal complexity.
By Ruilin Wang, Bo-Hong Wang, Elizabeth Kourbatski, Jun Bai, Hegang Chen, Ziyang Song, Gilles Boire, Marie Hudson, Yue Li
arXiv:2609.24480v1 Announce Type: cross
Abstract: Deploying Large Language Models (LLMs) in healthcare requires robust performance across two complementary dimensions - diagnostic reasoning: the conv...
By Kalash Shah, Kunal Singh, Snehan J, Shreyas Singh
arXiv:2607. 15314v1 Announce Type: new Abstract: Healthcare spans high-stakes communication, expert reasoning, and workflow execution, yet specialized LLMs that cover these use cases together remain limited.
By actAVA AI, :, Haolin Chen, Leon Qi, Steve Brown, Deon Metelski, Tao Xia, Joonyul Lee, Qixuan Wang, Kevin Riley, Frank Wang, Weiran Yao
As AI agents become increasingly capable of complex, long-horizon reasoning, rigorous and holistic evaluation is essential for measuring progress toward real-world healthcare applications. We introduce HealthAgentBench, a suite of 54 agentic healthcare tasks across 7 categories each with its unique environment.
arXiv:2608. 13476v1 Announce Type: new Abstract: We present Multi-Agent Reasoning and Coordination (MARC), an open-source framework that replaces monolithic LLM prompting with deterministic multi-agent orchestration for clinical reasoning.
By Saisha Shetty, Satvik Tripathi, Austin Lin, Colin Zhao, Theodore Kim, Don Enwerem, Jacinta Arnold, Shahriar Faghani, Tessa S Cook
The paper introduces MedTraj, a framework that constructs, evaluates, and optimizes multi‑step reasoning trajectories for medical AI agents. It parses each trajectory into observations, evidence, numbered steps, and a conclusion, scoring them on coherence, evidence support, hallucination, completeness, and traceability. Experiments on CareQA, PubMedQA, and CECMed show that incorporating quality‑weighted trajectory context improves reasoning coherence and correctness while significantly reducing hallucinations.
By Yunqi Zhu, Wensheng Zhang, Xuebing Yang
arXiv:2609.39566v1 Announce Type: new
Abstract: Foundation models can serve as clinical agents through tool-use harnesses. However, conventional medical benchmarks assess reasoning over preselected e...
By Minye Shao, Chaohui Yu, Yixuan Wu, Fan Wang, Ling Shao, Yang Long
arXiv:2512. 11682v2 Announce Type: replace Abstract: Therapeutic decision-making in clinical medicine constitutes a high-stakes domain in which AI guidance interacts with complex interactions among patient characteristics, disease processes, and pharmacological agents.
By Tim Cofala, Christian Kalfar, Jingge Xiao, Johanna Schrader, Michelle Tang, Wolfgang Nejdl
arXiv:2609.15161v1 Announce Type: cross
Abstract: Large language model (LLM) driven multi-agent systems have shown promise in complex clinical reasoning, yet existing approaches rely on static strate...
By Dongsheng Shi, Yue Li, Xin Yi, Linlin Wang
arXiv:2505. 02722v2 Announce Type: replace Abstract: Although large language models (LLMs) have demonstrated impressive reasoning capabilities across general domains, their effectiveness in real-world clinical practice remains limited.
By Junu Kim, Chaeeun Shim, Sungjin Park, Su Yeon Lee, Gee Young Suh, Chae-Man Lim, Seong Jin Choi, Song Mi Moon, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Sejoong Kim, Chami Im, Dong-Wan Kang, Yong Soo Kim, Hee-Joon Bae, Sung Yoon Lim, Han-Gil Jeong, Edward Choi