arXiv Machine Learning

EQPO: Equitable Group Relative Policy Optimization for Clinical Reasoning

arXiv:2510. 19893v2 Announce Type: replace Abstract: Medical AI systems demonstrated impressive diagnostic performance, yet they routinely show uneven accuracy across demographic groups, disadvantaging underrepresented populations.

arXiv AI
Jul 17

Demographically-Conditioned Synthetic Medical Images for Bias Mitigation and Bias Detection in Disease Classifiers

arXiv:2607. 14984v1 Announce Type: new Abstract: Per-subgroup fairness audits of medical image classifiers face a sample-size problem: minority subgroups in held-out test sets have so few samples that the resulting confidence intervals on per-subgroup performance are wider than the bias the audit is meant to detect.

By Mahmoud Ibrahim, Bart Elen, Chang Sun, Gokhan Ertaylan, Michel Dumontier
arXiv Computation and Language
Aug 28

CARE: Causally-Aligned Reasoning Exploration for Medical Large Language Models

CARE: Causally-Aligned Reasoning Exploration for Medical Large Language Models proposes a new framework to improve medical reasoning in LLMs. It introduces two key conditions—Causal Sufficiency and Proximal Learnability—to curate high-quality training trajectories, using agreement-based self-verification and dynamic entropy bounds. Experiments on medical multimodal and text-only benchmarks show that CARE outperforms competitors, reducing incorrect reasoning and enhancing training stability.

By Yucheng Zhou, Peng Luo, Qianning Wang, Chengzhong Xu, Jianbing Shen
arXiv Machine Learning
Jun 16

DRA-GRPO: Your GRPO Needs to Know Diverse Reasoning Paths for Mathematical Reasoning

arXiv:2505. 09655v5 Announce Type: replace-cross Abstract: Post-training LLMs with Reinforcement Learning, specifically Group Relative Policy Optimization (GRPO), has emerged as a paradigm for enhancing mathematical reasoning.

By Xiwen Chen, Wenhui Zhu, Peijie Qiu, Xuanzhao Dong, Hao Wang, Haiyu Wu, Huayu Li, Aristeidis Sotiras, Yalin Wang, Abolfazl Razi
arXiv Computer Vision
3d ago

From Image Interpretation to Clinical Reasoning: Upstream Physician-Context-Aware Multimodal Learning with Causal Reinforcement Learning

arXiv:2609.38924v1 Announce Type: new Abstract: Major adverse cardiovascular events (MACE) remain the leading cause of mortality worldwide. Opportunistic screening using routinely acquired clinical d...

By Jialu Pi, Yanan Ma, Weijie Chen, Owen Crystal, Shubham Trivedi, Stephen Xie, Anna Silverman, Matthew Stib, Chadi Ayoub, Reza Arsanjani, Imon Banerjee
arXiv AI
Aug 20

FairGlucose: A CGM Fairness Benchmark Reveals Subgroup Disparities Hidden in Population-Level Validation

FairGlucose is a 300‑patient CGM cohort balanced across 12 demographic strata, providing 132,480 forecasting samples and 3,945 behavioral events. Benchmarking 33 models on 2‑hour glucose forecasting revealed that population‑level validation masks significant subgroup disparities, with error ratios ranging from 0.8 to 1.4 and T1D patients experiencing 6 mg/dL higher error than T2D. The study shows that these gaps persist across all models, align with clinically hard cases, and vary with input‑length sensitivity, underscoring the need for subgroup‑disaggregated reporting in digital health AI.

By Junjie Luo, Xuzhe Zhi, Rui Han, Abhimanyu Kumbara, Anand K. Iyer, Mansur E. Shomali, Ritu Agarwal, Guodong Gordon Gao
arXiv AI
Aug 11

FoMoH: A clinically meaningful foundation model evaluation for structured electronic health records

arXiv:2505. 16941v4 Announce Type: replace-cross Abstract: Foundation models (FMs) promise to address core limitations of traditional supervised machine learning: (i) reliance on large amounts of labeled data, (ii) task specificity, and (iii) poor transportability.

By Vincent Jeanselme, Zilin Jing, Aparajita Kashyap, Chao Pang, Florent Pollet, Young Sang Choi, Xinzhuo Jiang, Yuta Kobayashi, Yanwei Li, Sara Matijevic, Karthik Natarajan, Shalmali Joshi
arXiv AI
Jun 30

An AI agent for treatment reasoning over a biomedical tool universe

arXiv:2606. 28692v1 Announce Type: new Abstract: Treatment reasoning underpins every therapeutic decision, integrating disease context, comorbidities, medications, contraindications, and evolving biomedical knowledge to select an appropriate therapy.

By Shanghua Gao, Ayush Noori, Richard Zhu, Curtis Ginder, Zhenglun Kong, Xiaorui Su, Justin Kauffman, Benjamin S. Glicksberg, Joshua Lampert, Ankit Sakhuja, Ashwin Sawant, ATHENA-R1 Evaluation Consortium, David A. Clifton, Noa Dagan, Ran Balicer, Marinka Zitnik
arXiv AI
Jul 9

CompDiff: Hierarchical Compositional Diffusion for Fair and Zero-Shot Intersectional Medical Image Generation

arXiv:2603. 16551v2 Announce Type: replace-cross Abstract: Generative models are increasingly used to augment medical imaging datasets for fairer AI, yet a key assumption often goes unexamined: that generators produce equally high-quality images across demographic groups.

By Mahmoud Ibrahim, Bart Elen, Chang Sun, Gokhan Ertaylan, Michel Dumontier
arXiv AI
Aug 12

CARE: Confidence-Aware Reasoning for Reliable Medical VQA

arXiv:2608. 10964v1 Announce Type: cross Abstract: Reinforcement Fine-Tuning (RFT) has enabled medical Multimodal Large Language Models (MLLMs) to produce Chain-of-Thought (CoT) reasoning for visual question answering, yet these models suffer from $\textit{confidence miscalibration}$---a systematic gap between expressed certainty and actual diagnostic accuracy that undermines clinical trust.

By Yuetian Du, Yucheng Wang, Zhenyuan Chen, Luyuan Chen, Rongyu Zhang, Jinjian Zhang, Wei Zhou, Zhijie Xu, Ming Kong, Zhan Zhou, Jie Liu, Qiang Zhu