arXiv Machine Learning

Translation of Black-Box Clinical Prediction Models into Standalone Transparent Nomograms: Temporal External Validation in Heart Transplantation

Hugging Face Trending Papers
Aug 4

Paired Recipient-based Evaluation of Survival Prediction for Deceased Donor Kidney Transplants

There has been significant interest in using machine learning algorithms to predict kidney transplant outcomes, such as the number of years until a graft inevitably fails. These prediction algorithms could possibly be used for pre-transplant donor-recipient matching to identify more compatible donors and recipients and thus improve post-transplant outcomes.

arXiv Machine Learning
Jun 2

Benchmarking Waitlist Mortality Prediction in Heart Transplantation Through Time-to-Event Modeling using New Longitudinal UNOS Dataset

arXiv:2507. 07339v2 Announce Type: replace-cross Abstract: Decisions about managing patients on the heart transplant waitlist are currently made by committees of doctors who consider multiple factors, but the process remains largely ad-hoc.

By Yingtao Luo, Reza Skandari, Carlos Martinez, Arman Kilic, Rema Padman
arXiv Machine Learning
Sep 18

Interpretable and Calibrated Classification of Clinical Data Using Supervised Feature Binarization

The paper introduces a statistically grounded framework for interpretable, rule-based clinical classification using Bernoulli Naïve Bayes (BNB). It employs supervised chi‑square‑guided binarization to convert continuous medical variables into binary indicators, enabling BNB to handle continuous data while maintaining transparency. On three benchmark datasets—Pima Indians Diabetes, Wisconsin Breast Cancer, and Heart Failure Prediction—the method achieved AUCs of 0.800, 0.984, and 0.919, respectively, and demonstrated reliable probability calibration through cross‑validated analysis and post‑hoc beta calibration.

By Antony Garcia, Adrian Noriega, Gabrielle Britton, Xinming Huang
arXiv Machine Learning
Aug 28

Private and interpretable clinical prediction with quantum-inspired tensor train models

The paper demonstrates that publicly available clinical machine learning models, such as logistic regression (LR), pose significant privacy risks because attackers can recover model parameters and identify training cohorts through various membership inference attacks. The authors show that even small cohorts can be reliably identified and that common practices like cross-validation can worsen the risk. To mitigate this, they propose a quantum-inspired defense that tensorizes discretized models into tensor trains (TTs), which obfuscates parameters, preserves accuracy, and maintains interpretability while providing black‑box protection comparable to Differential Privacy.

By Jos\'e Ram\'on Pareja Monturiol, Juliette Sinnott, Roger G. Melko, Mohammad Kohandel
arXiv AI
Sep 1

Scalable Clinical Data Infrastructure and Comparative ML Evaluation for Hospitalisation Risk Prediction in Elderly Patients with Multiple Long-Term Conditions using CPRD

arXiv:2608.29419v1 Announce Type: cross Abstract: Deep learning architectures are increasingly proposed for patient trajectory modeling in electronic health records (EHRs), yet their advantage over s...

By Asra Aslam, Volodymyr Chapman, Maurice M. O'Connell, Aseel S. Abuzour, Michael Abaho, Danushka Bollegala, Gary Leeming, Eduard Shantsila, Andrew Clegg, Lauren E. Walker, Iain Edward Buchan, Samuel D. Relton
arXiv Machine Learning
Sep 22

From Latent Biomarkers to Clinical Rules: Embedding-Guided Rule Mining and Attribution-Based Translation for Interpretable Tabular Learning

The paper introduces a four-step pipeline that mines decision rules in the latent space of an FT-Transformer and then translates those rules back into measurable clinical features. By treating embedding dimensions that separate patient groups as latent biomarkers, small decision trees are used to extract rules, which are then mapped to raw features using gradient-input saliency and CLS attention attribution. Across six public clinical datasets, the translated rules generally outperformed raw-feature rules, achieving significant AUROC gains, though some high-performing latent rules could not be fully captured by simple raw-feature conditions.

By Majid Lotfian Delouee, Hamed Ayoobi, Sjors G. J. G. In 't Veld, Martijn C. Schut