arXiv:2412. 17228v4 Announce Type: replace Abstract: Background: Clinical trials are essential to advancing cancer treatments, but fewer than 10% of adults with cancer enroll in therapeutic trials.
arXiv:2609.01202v1 Announce Type: cross Abstract: Clinical trials are essential for advancing cancer care and drug development, but many fail because of insufficient patient enrollment. While there i...
arXiv:2608.28974v1 Announce Type: new Abstract: Clinically relevant oncology information is distributed across heterogeneous, longitudinal documentation, creating substantial abstraction burden and r...
OpenMTB‑Audit is an open‑source benchmark that tests large language models on 500 synthetic non‑small cell lung cancer cases, covering five adversarial error categories and four safety labels: Supported, Partially Supported, Unsupported, and Insufficient Information. The study found that all eight tested LLMs over‑refused Partially Supported recommendations, collapsing labels to achieve high safety scores. A deterministic seven‑module framework, MTB‑AuditAgent, was introduced to reduce over‑refusal to 6.7% and reach 91.2% accuracy, while an oncologist annotation study highlighted disagreement around the boundary between information sufficiency and treatment optimization.
arXiv:2607. 08602v1 Announce Type: new Abstract: Hepatocellular carcinoma (HCC) is a common malignancy and a leading cause of cancer-related mortality.
The paper presents a method for extracting key information from OCR‑digitized clinical reports, addressing challenges posed by heterogeneous documents and noisy OCR output. It introduces an open key space that is iteratively mined, normalized, clustered, and verified to build a canonical key inventory, and defines key coverage as a metric for inventory completeness. Experiments on reports from over 20 hospitals using a 0.2B BERT model show that performance improves steadily with key coverage, achieving high F1 scores when the top 90 keys are covered and outperforming a fine‑tuned Qwen3‑0.6B baseline.
arXiv:2608.22108v1 Announce Type: new Abstract: Breast Cancer Multidisciplinary Team (MDT) meetings manage increasingly complex cases under considerable time pressure, and documentation requirements...
arXiv:2606. 11830v1 Announce Type: new Abstract: Background.
CRISS is a retrieval‑augmented generation chatbot designed to aid cancer registrars by providing rapid, citation‑supported answers to complex coding and staging questions. It uses a domain‑specific knowledge base of national registry standards, indexed as dense embeddings, to retrieve relevant passages that ground responses generated by a large language model. In evaluations, RAG configurations consistently outperformed non‑RAG baselines across easy, medium, and hard questions, achieving higher grounding and semantic similarity scores while maintaining human oversight for final decisions.
Synthetic Hospital is an open, fully synthetic longitudinal electronic health record benchmark created from public medical education material. It contains 1,268 patients and 5,602 encounters, with every diagnosis, finding, and temporal relation grounded in standard ontologies and traceable back to its source. Physicians could not reliably distinguish its records from real charts, and current frontier AI models perform significantly below human experts on tasks such as reconstructing problem lists and summarizing charts.
arXiv:2606. 17405v1 Announce Type: new Abstract: Clinical decision support AI systems (CDSASs) must adapt to evolving patient conditions in real-time while adhering to strict safety constraints.
The paper introduces TRACE, a method that removes duplicated text—known as note bloat—from clinical notes by leveraging EHR metadata and frequency-based de‑duplication. Across 5.3 million notes from diverse patient cohorts, TRACE eliminated 47.3 % of chart text while preserving information extraction and prediction performance, with only 0.3–6.6 % of removed content being author‑generated. The authors project that applying TRACE could yield net savings of $1.00 M to $13.58 M over three years at a large academic center, depending on model pricing schemes.
ClinAgent is a conversational system that uses a ReAct-based LLM agent to retrieve and synthesize clinical trial information from multiple sources such as ClinicalTrials.gov, PubMed, and a local dataset. The agent iteratively reasons over user queries, selects appropriate tools, and refines its actions to provide grounded, up-to-date responses in natural language across multi-turn interactions. Evaluation across three phases shows that DeepSeek (thinking mode) excels in planning quality while Gemini 3.0 Flash delivers the highest overall performance and expert ratings, demonstrating the promise of agentic AI for improving clinical trial data access.