Brain tissue microstructure estimation with machine learning provides higher computational efficiency than conventional fitting. However, machine learning still presents important limitations that hamper its clinical utility.
The paper introduces a control‑variable framework for deep neural networks to mitigate omitted variable bias, particularly shortcut learning where covariates like demographics influence predictions. It refits the final layer of a pre‑trained network using cross‑fitting with ridge penalisation, orthogonalises covariate effects, and marginalises predictions over covariate distributions to achieve unbiased, interpretable results. Experiments on simulated images and neuroimaging data show consistent estimation of true effects and performance close to models trained on unconfounded data.
By Manuel Pfeuffer, Roshan Prakash Rane, Kerstin Ritter, Sonja Greven
arXiv:2606. 15837v1 Announce Type: cross Abstract: Deep neural networks (DNNs) frequently fail to generalize to out-of-distribution (OOD) medical images because of variations in scanners and acquisition protocols.
By Jimut B. Pal, Suyash P. Awate
InstEditSeg is a generative framework that treats medical segmentation as an instruction-driven image editing task. Instead of producing binary masks, it renders a color-coded overlay on the original image guided by textual instructions, leveraging latent diffusion models to align with natural image distributions and reduce domain gaps. The method incorporates a DINOv3 visual encoder and a multi-scale feature pyramid fused into the diffusion U‑Net, and uses a dual‑branch classifier‑free guidance strategy to lower inference cost, achieving competitive accuracy on polyp and skin lesion datasets while improving cross‑domain generalization and multi‑lesion segmentation.
By Ziquan Liu, Zhewei Zhu, Xuyang Shi
arXiv:2607. 09892v1 Announce Type: cross Abstract: We introduce DenseAR, a new generative paradigm that reformulates autoregressive image generation as coarse-to-fine next-dense-stride prediction using a compact single-scale tokenizer.
By Chicago Y. Park, Jialin Mao, Xiaojian Xu, Taha Kass-Hout, Ulugbek S. Kamilov, Cao Xiao
arXiv:2510.17072v2 Announce Type: replace
Abstract: Regression with non-Euclidean responses---e.g., probability distributions, networks, symmetric positive-definite matrices, and compositions---has b...
By Kyum Kim, Yaqing Chen, Paromita Dubey
arXiv:2604. 22700v2 Announce Type: replace Abstract: Modeling and predicting neurodegenerative disease progression from medical images remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning.
By Nivetha Jayakumar, Swakshar Deb, Bahram Jafrasteh, Qingyu Zhao, Miaomiao Zhang
arXiv:2609.15669v1 Announce Type: cross
Abstract: Multimodal image registration is a key component of many clinical workflows, yet it remains challenging because corresponding anatomical structures o...
By Matteo Barbieri, Giammarco La Barbera, Juan Pablo De La Plata, Sabine Sarnacki, Isabelle Bloch, Pietro Gori
arXiv:2505. 21736v2 Announce Type: replace-cross Abstract: Translation equivariance is a central reason convolutional neural networks have been successful in computer vision.
By Siqi Fang, Zachary Schlamowitz, Andrew Bennecke, Daniel J. Tward
arXiv:2606. 19651v1 Announce Type: new Abstract: Three-dimensional (3D) brain MRI is central to clinical neurology and neuro-oncology, where generative models could augment under-represented cohorts, simulate disease trajectories, and support privacy-preserving data sharing.
By Max Van Puyvelde, Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert
arXiv:2504. 06299v2 Announce Type: replace-cross Abstract: Multimodal prediction models based on imaging and clinical data are increasingly used for clinical decision support, yet their interpretability remains limited.
By Lisa Herzog, Jonas Br\"andli, Maurice Schneeberger, Loran Avci, Nordin Dari, Martin H\"ansel, Hakim Baazaoui, Pascal B\"uhler, Susanne Wegener, Beate Sick
arXiv:2606. 01172v1 Announce Type: new Abstract: Modeling unknown latent functions from finite, irregularly sampled measurements is a recurring challenge across science and engineering.
By Peiman Mohseni, Nick Duffield, Raymond K. W. Wong