The paper introduces MedREAL, a unified framework that aligns linguistic reasoning with spatial grounding for medical visual question answering and segmentation. MedREAL employs Seg Anchored Reasoning Pooling (SARP) to extract semantic evidence from segmentation tokens and a Reasoning-to-Visual (R2V) fusion mechanism to integrate these features into a segmentation pipeline. Using the newly created MedRAVS-13K dataset, MedREAL achieves superior performance, reporting 68.49% gIoU and 70.47% cIoU, and generates evidence masks that consistently match textual diagnoses.
By Haowen Gu, Gensheng Pei, Junzhu Mao, Qiong Wang, Mingwu Ren, Yazhou Yao
arXiv:2601.06847v2 Announce Type: replace-cross
Abstract: Vision-Language Models (VLMs) can generate convincing clinical narratives, yet frequently struggle to visually ground their statements. We po...
By Mengmeng Zhang, Xiaoping Wu, Hao Luo, Fan Wang, Yisheng Lv
arXiv:2608.22713v1 Announce Type: new
Abstract: Clinical diagnosis requires progressive integration of patient history, physical examination, laboratory findings, medical images, and diagnostic-infor...
By Yufan Wang, Rui Yang, Yi Liu, Yi Lin, Yifan Peng
arXiv:2601.09879v2 Announce Type: replace-cross
Abstract: Recent progress in medical vision-language models (VLMs) has achieved strong performance on image-level text-centric tasks such as report gen...
By Yang Xing, Jiong Wu, Savas Ozdemir, Ying Zhang, Yang Yang, Wei Shao, Kuang Gong
arXiv:2607. 25933v1 Announce Type: cross Abstract: Clinical diagnostic evaluation should not only assess whether models can provide correct diagnoses, but also reflect the realities of clinical practice, including progressive disclosure of multimodal information, dynamic updating of diagnostic hypotheses, and continuous refinement of clinical reasoning.
By Rui Yang, Weihao Xuan, Yi Lin, Zhuhan Bao, Jonathan Chong Kai Liew, Matthew Yu Heng Wong, Nicol\'as Lescano, Nikita R. Paripati, Emily Ling-Lin Pai, Jiarui Liu, Heli Qi, Heng-Jui Chang, Benny Kai Guo Loo, Huitao Li, Kunyu Yu, Yufan Wang, Chuan Hong, Shijian Lu, Douglas Teodoro, Naoto Yokoya, Ross Koppel, Mona Diab, Hua Xu, David W. Bates, Nan Liu, Yifan Peng
The rapid advancement of vision-language models (VLMs) has accelerated progress in computational pathology; however, whole-slide image (WSI)-based pathology report generation remains limited by the sc...
arXiv:2606. 17958v1 Announce Type: cross Abstract: Semi-supervised medical image segmentation has emerged as a dominant research problem in medical image analysis, mitigating annotation scarcity by leveraging consistency regularization on unlabeled data.
By Yuming Chen, Yuxin Xie, Tao Zhou, Yi Zhou
AlphaRAD introduces a grounded zero‑shot classification framework for chest radiology that leverages structured medical concepts extracted from reports and a novel α‑Corrected Binary Cross‑Entropy loss to reduce in‑batch noise. It also presents FLaS, a lightweight cross‑modal fusion module that factorizes VLPM representations into independent subspaces, improving spatial grounding without adding parameters. The method achieves state‑of‑the‑art performance on 16 classification benchmarks and sets new records on several grounding, phrase‑grounding, and segmentation datasets.
By Jianzhong You, Yuan Gao, Chris McIntosh
Multimodal large language models (MLLMs) hold immense potential to revolutionize clinical practice, yet deploying them in the medical domain is fundamentally a vision-centric challenge: models must absorb knowledge from heterogeneous 2D and 3D medical images, and evaluation protocols must align with radiologists' clinical practice and provide an accurate, fine-grained and factualness-driven assessment. In this paper, we introduce ClinFusion, a vision-centric MLLM designed for holistic medical understanding that systematically addresses these limitations.
arXiv:2607. 24743v1 Announce Type: cross Abstract: Multimodal large language models (MLLMs) hold immense potential to revolutionize clinical practice, yet deploying them in the medical domain is fundamentally a vision-centric challenge: models must absorb knowledge from heterogeneous 2D and 3D medical images, and evaluation protocols must align with radiologists' clinical practice and provide an accurate, fine-grained and factualness-driven assessment.
By Hangjie Yuan, Yichen Qian, Zhiwei Tang, Xianzhe Xu, Lirong Wu, Sicheng Yang, Jinwang Wang, Pengju Wang, Zhitao Zeng, Yizeng Han, Yan Xing, Shengxuan Luo, Tao Feng, Qing Xie, Weigen Yao, Yi Yang, Zuozhu Liu, Jiasheng Tang, Shaocheng Wang, Jitao Wang, Jiahong Dong, Weihua Chen, Feng Xu, Fan Wang
MedSAM-3 is a text‑promptable medical segmentation model that builds on the Segment Anything Model (SAM) by fine‑tuning it with medical images and semantic concept labels. It enables precise anatomical segmentation through open‑vocabulary text descriptions, moving beyond purely geometric prompts. The accompanying MedSAM-3 Agent incorporates multimodal large language models to perform complex reasoning and iterative refinement, and experiments across X‑ray, MRI, ultrasound, CT, and video modalities show it outperforms existing specialist and foundation models.
By Anglin Liu, Xu R. Cao, Yifan Shen, Yi Lu, Xiang Li, Qianqian Chen, Jintai Chen
arXiv:2609.37283v1 Announce Type: new
Abstract: Medical multimodal large language models (MLLMs) are increasingly expected not only to answer clinical questions, but also to localize the visual evide...
By Xuyang Cao, Enyou Liu, Jun Zhao, Zhuoyun Liu, Jintao Fei, Leo