arXiv Computation and Language

OverdoseMoE: A Multi-Expert Framework for Opioid Overdose Risk Prediction

arXiv Computation and Language
Sep 23

Learning Diagnostic Reasoning for Decision Support in Toxicology

The paper introduces DeToxR, a reinforcement‑learning‑enhanced large language model designed to support decision making in acute toxicology cases. It fuses unstructured narratives from paramedics and patients with structured vital‑sign data to predict co‑ingested substances across 14 classes. In preliminary validation, DeToxR outperforms baseline models, achieving higher micro‑F1 and recall scores for poison identification.

By Nico Oberl\"ander, David Bani-Harouni, Tobias Zellner, Nassir Navab, Florian Eyer, Matthias Keicher
arXiv Machine Learning
Aug 6

A Comparative Study of Feature Selection Methods for EHR Diagnosis Codes in Opioid Use Disorder Prediction

arXiv:2608. 04180v1 Announce Type: new Abstract: Feature selection is a critical step in electronic health record (EHR)-based predictive modeling, where input variables are often high-dimensional, sparse, noisy, and redundant.

By Zihan Ding, Yinan Liu, Tengfei Ma, Rachel Wong, George Leibowitz, Benjamin Littenberg, Xia Zheng, Richard N. Rosenthal, Fusheng Wang
arXiv Machine Learning
Sep 22

Toward Fairness in Machine Learning Models for Predicting Treatment Retention and Premature Discontinuation in Medication for Opioid Use Disorder

The paper evaluates machine learning models that predict retention and premature discontinuation in medication for opioid use disorder (MOUD). Using the Treatment Episode Data Set-Discharges (TEDS‑D) from 2015‑2019, the authors trained four models and examined overall performance as well as subgroup error rates by race, ethnicity, age, and sex. They also tested bias‑mitigation techniques, finding that these can reduce but not eliminate performance gaps without harming predictive accuracy.

By Tongnian Wang, Carolina Vivas-Valencia, Cici Bauer, Yanmin Gong, Kim-Kwang Raymond Choo, Yuanxiong Guo
arXiv AI
Jul 24

A Knowledge-Injection Framework for Zero-Shot Adaptation of LLMs to Delirium Prediction

arXiv:2607. 20453v1 Announce Type: cross Abstract: Large language models show promise for clinical prediction, but zero-shot performance on specialized tasks is limited by incomplete domain knowledge, especially for smaller locally deployable models.

By Jessica Sena, Shesadree Priyadarshani, Miguel Contreras, Bharat Gandhi, Scott Siegel, Subhash Nerella, Parisa Rashidi
arXiv AI
Sep 25

Multimodal AI predicts clinical outcomes of drug combinations from preclinical data

arXiv:2503. 02781v3 Announce Type: replace-cross Abstract: Predicting clinical outcomes from preclinical data is essential for selecting safe and effective drug combinations and for reducing late-stage failures.

By Yepeng Huang, Xiaorui Su, Varun Ullanat, Intae Moon, Ivy Liang, Lindsay Clegg, Damilola Olabode, Ruthie Johnson, Nicholas Ho, Megan Gibbs, Alexander Gusev, Bino John, Marinka Zitnik