This study assessed whether day‑1 multimodal MRI can improve prediction of three‑month functional outcome after acute ischemic stroke. Using pretrained ResNet embeddings from ADC, DWI, and FLAIR scans combined with clinical data, the authors found that clinical‑only models performed well (AUC≈0.90), while MRI‑only models were less discriminative (AUC≈0.67‑0.73). Among multimodal combinations, FLAIR‑clinical fusion yielded the best performance (AUC≈0.95), with age, NIHSS subscores, ADC lesion burden, and learned FLAIR features identified as key contributors.
arXiv:2506.15626v3 Announce Type: replace-cross Abstract: $\textbf{Objective:}$ Brain-predicted age difference (BrainAGE) is a neuroimaging biomarker reflecting brain health. However, training robust...
The paper introduces Neuro‑JEPA, a sparse multimodal foundation model that learns unified representations of brain MRI across T1w, T2w, and FLAIR sequences using a latent predictive objective and a Mixture‑of‑Experts architecture. It was pretrained on over 1.5 million scans from 428,647 studies and systematically evaluates architectural, masking, objective, and sparsity choices for robust multimodal representation learning. Across 47 tasks from three health systems and 12 public datasets, Neuro‑JEPA consistently outperforms a simple CNN baseline, demonstrating its effectiveness for both clinical and research applications.
arXiv:2610.34529v1 Announce Type: cross Abstract: Background/Objectives: Rapid differentiation of ischemic and hemorrhagic stroke subtypes is vital for acute management. Although current deep learnin...
The study presents an explainable multimodal deep‑learning framework that combines a 3D CNN for T1‑weighted MRI with a feedforward network for harmonized clinical and demographic data to diagnose Alzheimer’s disease. Using 6,479 ADNI records and 1,703 OASIS‑3 records, the authors compare various model configurations on three‑way and pairwise diagnostic tasks, finding that performance and explanations vary by task, modality, fusion strategy, and cohort. SHAP and Integrated Gradients consistently highlight the MMSE score as the most influential tabular feature, while CAM‑based explanations differ across model setups and cohorts, indicating that explainability is not a stable property under cohort shift.
arXiv:2601. 20503v2 Announce Type: replace-cross Abstract: White matter hyperintensities (WMH) and ischaemic stroke lesions (ISL) are key imaging biomarkers of cerebral small vessel disease (SVD) detectable on magnetic resonance imaging (MRI).
arXiv:2606. 17115v1 Announce Type: cross Abstract: Foundation models (FMs) have emerged as powerful representation extractors for medical data, yet their generalizability to datasets under distribution shift remains underexplored.
arXiv:2504. 06299v2 Announce Type: replace-cross Abstract: Multimodal prediction models based on imaging and clinical data are increasingly used for clinical decision support, yet their interpretability remains limited.
This study presents a domain-aware deep learning framework based on nnU-Net for segmenting ischemic stroke lesions on non‑contrast CT scans and quantifying net water uptake (NWU). Trained on data from Hamburg and the Acute Ischemic Stroke Dataset, the model was fine‑tuned on small target‑domain subsets from Boston and ISLES, achieving median Dice scores of 0.68 and 0.56 for lesions ≥30 mL, and an NWU mean absolute error of 1.37 percentage points on the Boston cohort. The results demonstrate that target‑domain adaptation can enable accurate NCCT‑only infarct segmentation and low‑error NWU estimation across heterogeneous multicenter datasets.
The paper introduces a bi‑temporal framework that links admission computed tomography perfusion (CTP) data with follow‑up diffusion‑weighted MRI (DWI) outcomes in acute ischemic stroke. By extracting statistical, radiomic, and deep‑learning features from CTP and classifying tissue into six outcome‑aware regions, the authors demonstrate that CTP signatures can distinguish salvaged versus infarcted penumbra and identify non‑hypoperfused tissue that later infarcts. Cross‑dataset validation on the ISLES'24 dataset confirms consistent feature‑space separations, suggesting that admission CTP contains richer outcome information than traditional core‑penumbra delineation.
arXiv:2609.22271v1 Announce Type: new Abstract: Multimodal stroke recurrence prediction requires effective integration of heterogeneous clinical and imaging data, yet modality imbalance often causes...
arXiv:2607. 03568v1 Announce Type: cross Abstract: Objective: Accurate identification of acute ischemic infarcts on diffusion-weighted magnetic resonance imaging (DWI) is a critical prerequisite for reliable lesion quantification and effective clinical decision support in the management of cerebrovascular events.
arXiv:2604. 27277v3 Announce Type: replace-cross Abstract: Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data.