The study introduces a Riemannian shape‑space framework for analyzing age‑related morphological changes in the midsagittal corpus callosum (CC) using 128 landmarks embedded in Kendall shape space. Applied to the OASIS‑1 cohort, multivariate geodesic regression identifies anterior sub‑regions (Genu and Anterior Body) as the primary sites of age‑related deformation, outperforming Euclidean benchmarks. In Alzheimer’s patients, age explains less than 0.5% of shape variance, and a tangent‑space classifier achieves an age‑group AUC of 0.791 from 2D contour data alone.
arXiv:2610.34825v1 Announce Type: new Abstract: Diffusion MRI (dMRI) provides information about white matter microstructure that can support brain age prediction. However, many existing prediction mo...
Brain-PACE is a deep Siamese MRI framework that directly estimates the pace of structural brain ageing from paired T1‑weighted MRI scans, extending the LILAC model with spatial attention, soft label distribution learning, and a Cramér distance objective. In a study of participants with mild cognitive impairment, 42.6 % showed accelerated ageing, and faster Brain‑PACE scores correlated with greater functional and cognitive impairment as well as higher regional tau burden in key brain regions. The method improves probabilistic performance, reduces prediction bias, and provides predictive uncertainty, offering a complementary longitudinal imaging phenotype sensitive to early neurodegeneration.
arXiv:2608. 08173v1 Announce Type: cross Abstract: Longitudinal MRI enables sensitive measurement of structural brain change for studying aging and neurodegenerative disease.
arXiv:2511.15188v3 Announce Type: replace Abstract: Accurate brain-age estimation from structural MRI provides a valuable biomarker for studying healthy aging and neurodegenerative disease. We propos...
The paper introduces DB‑SUiT, a surface‑based diffusion bridge that translates cortical MRI to PET images directly on the cortical manifold. It employs a conditional spherical U‑shaped vision Transformer to capture multi‑scale surface features and long‑range dependencies while incorporating demographic and subcortical information. Evaluations on two dementia datasets show that the synthesized PET surfaces outperform MRI and PET volumes in automated classification and achieve high diagnostic accuracy in a blinded reader study.
The paper introduces a two-stage multi‑modal MRI framework that processes different MRI modalities independently before integrating them through late fusion. First, the model estimates a probability distribution over six developmental stages, then it predicts age using probability‑weighted, stage‑specialized experts. Experiments across nine datasets—from fetal to elderly—show the method outperforms existing baselines, reducing mean absolute error by 13% and 78% in in‑domain and out‑of‑domain settings, and multi‑modal integration yields 12‑13% performance gains. Analysis on ADNI clinical groups indicates that the predicted brain age gap could help characterize Alzheimer’s‑related brain aging.
arXiv:2508.17171v3 Announce Type: replace Abstract: Imaging biomarkers in magnetic resonance imaging (MRI) are important tools for diagnosing, tracking and treating Alzheimer's disease (AD). Neurofib...
arXiv:2608. 05132v1 Announce Type: cross Abstract: Predicting how a subcortical structure's shape will evolve from a few prior scans could support prognosis and clinical-trial enrichment.
arXiv:2606. 17022v1 Announce Type: cross Abstract: A central objective of machine learning is to identify structure and patterns in data.
arXiv:2608. 06971v1 Announce Type: cross Abstract: This paper introduces Mixtures of Geodesic Factor Analyzers (MGFA) on Riemannian homogeneous spaces.
FiberGeoText (FGT) is a vision‑language model that clusters short‑range superficial white matter streamlines from ultra‑high‑resolution diffusion MRI into population‑level groups. It jointly encodes each streamline’s 3‑D trajectory, cortical anatomical context (via text from multiple parcellation schemes), and shape, using a pretrained large language model to unify heterogeneous anatomical descriptions. Evaluations on 0.76 mm diffusion data show that FGT outperforms state‑of‑the‑art methods in cortical parcel coherence, shape consistency, cluster‑size consistency, and cross‑subject correspondence, and it generalizes well to unseen subjects, recovering 96.7 % of learned clusters.
arXiv:2609.15888v1 Announce Type: cross Abstract: Deep networks trained on structural MRI for Alzheimer's disease (AD) staging often reach reasonable accuracy while attending to anatomically irreleva...