arXiv AI

Performance of Clinical AI System and Physicians and Frontier Language Models in primary care diagnostics

The study compared the performance of the AI system Doctorina, eight physicians, and four frontier language models on 150 synthetic Polish primary‑care consultations. Doctorina achieved 82.0% top‑1 concordance, outperforming physicians (57.0%) by 25 percentage points, and also led in diagnostic workup and treatment scores. A second run confirmed these advantages across all measured outcomes.

arXiv Computation and Language
Aug 21

HealMed: Multilingual Evaluation of Large Language Models in Medicine

arXiv:2608. 19981v1 Announce Type: new Abstract: We present HealMed, an expert-reviewed benchmark for multilingual evaluation of large language models in medicine.

By Yingjian Chen (Drew), Fan Gao (Drew), Sherry T. Tong (Drew), Haoyu Zhang (Drew), Aosong Feng (Drew), Kevin W. Jin (Drew), Xing Wu (Drew), Jinghui Lu (Drew), Abdul Samad (Drew), Akbar Faruqi (Drew), Cesar Caraballo (Drew), Cibele Brand\~ao (Drew), Dhruva (Drew), Gupta, Eunji Jeon, Gabriel Madera-Santiago, Geon Lee, Hugo Toshio Itikawa, Insook Cho, Isabelli Martins, Isarar Siddique, Israr Ahmed, Jihyo Kwak, Kanyakorn Veerakanjana, Luis Guilherme Cardoso, Minjin Kim, Piyalitt Ittichaiwong, Renee Dua, Santiago Gudi\~no-Rosales, Xiujie Chen, Zeo Lapalus, Zixin Xu, Michihiro Yasunaga, Rex Ying, Heuiseok Lim, Jaewoo Kang, Chanjun Park, Hang Jiang, Ethan Goh, Hyunjae Kim, Edison Marrese-Taylor, Yusuke Iwasawa, Yutaka Matsuo, Qingyu Chen, Irene Li
arXiv AI
Jun 17

First, do NOHARM: towards clinically safe large language models

arXiv:2512. 01241v3 Announce Type: replace-cross Abstract: Large language models (LLMs) are routinely used by physicians and patients for medical advice, yet their clinical safety profiles remain poorly characterized.

By David Wu, Fateme Nateghi Haredasht, Saloni Kumar Maharaj, Priyank Jain, Jessica Tran, Matthew Gwiazdon, Arjun Rustagi, Jenelle Jindal, Jacob M. Koshy, Vinay Kadiyala, Anup Agarwal, Bassman Tappuni, Brianna French, Sirus Jesudasen, Christopher V. Cosgriff, Rebanta Chakraborty, Jillian Caldwell, Susan Ziolkowski, David J. Iberri, Robert Diep, Rahul S. Dalal, Kira L. Newman, Kristin Galetta, J. Carl Pallais, Nancy Wei, Kathleen M. Buchheit, David I. Hong, Vartan Pahalyants, Ernest Y. Lee, Allen Shih, Tamara B. Kaplan, Vishnu Ravi, Sarita Khemani, Thomas A. Buckley, April S. Liang, Daniel Shirvani, Advait Patil, Nicholas Marshall, Kanav Chopra, Joel Koh, Adi Badhwar, Anastasia Perez, Austin J. Schoeffler, Mahbuba Tusty, Chase M. Walton, Liam G. McCoy, David J. H. Wu, Yingjie Weng, Sumant Ranji, Kevin Schulman, Nigam H. Shah, Jason Hom, Arnold Milstein, Arjun K. Manrai, Adam Rodman, Jonathan H. Chen, Ethan Goh
arXiv AI
Jul 15

First, do NOHARM: a medical safety benchmark and randomized study of physician and AI teaming on clinical consultations

arXiv:2512. 01241v4 Announce Type: replace-cross Abstract: Large language models (LLMs) and medical AI tools are routinely used by physicians and patients for medical advice, yet their clinical safety profiles remain poorly characterized.

By David Wu, Fateme Nateghi Haredasht, Saloni Kumar Maharaj, Priyank Jain, Jessica Tran, Matthew Gwiazdon, Arjun Rustagi, Jenelle Jindal, Jacob M. Koshy, Vinay Kadiyala, Anup Agarwal, Bassman Tappuni, Brianna French, Sirus Jesudasen, Christopher V. Cosgriff, Rebanta Chakraborty, Jillian Caldwell, Susan Ziolkowski, David J. Iberri, Robert Diep, Rahul S. Dalal, Kira L. Newman, Kristin Galetta, J. Carl Pallais, Nancy Wei, Kathleen M. Buchheit, David I. Hong, Vartan Pahalyants, Ernest Y. Lee, Allen Shih, Tamara B. Kaplan, Vishnu Ravi, Sarita Khemani, Thomas A. Buckley, April S. Liang, Daniel Shirvani, Advait Patil, Nicholas Marshall, Kanav Chopra, Joel Koh, Adi Badhwar, Anastasia Perez, Austin J. Schoeffler, Mahbuba Tusty, Chase M. Walton, Liam G. McCoy, David J. H. Wu, Yingjie Weng, Sumant Ranji, Kevin Schulman, Nigam H. Shah, Jason Hom, Arnold Milstein, Arjun K. Manrai, Adam Rodman, Jonathan H. Chen, Ethan Goh
arXiv Computation and Language
Sep 17

Large Language Models Versus Physicians in Traditional Chinese Medicine: A Real-World Clinical Case Evaluation

arXiv:2609.17544v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly being explored for clinical applications, yet their assessment for real-world traditional Chinese medicin...

By Jiacheng Xie, Xiaoting Tang, Yang Yu, Jinpu Li, Shouli Li, Congcong Jing, Yantao Yang, Zhiyong Zhao, Ziyang Zhang, Qilin Song, Guanghui An, Dong Xu
arXiv AI
Jun 15

Can LLMs Accurately Score Medical Diagnoses and Clinical Reasoning?

arXiv:2604. 14892v3 Announce Type: replace-cross Abstract: Evaluating medical AI systems using expert clinician panels is costly and slow, motivating the use of large language models (LLMs) as alternative adjudicators.

By Amy Rouillard, Sitwala Mundia, Linda Camara, Ziyaad Dangor, Michael Cameron Gramanie, Ismail Kalla, Shabir A. Madhi, Kajal Morar, Marlvin T. Ncube, Haroon Saloojee, Bruce A. Bassett
arXiv AI
Jul 28

OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries

arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.

By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv AI
Sep 10

Teaching agentic AI to generalize expert diagnostic reasoning in rare diseases

arXiv:2606.16149v5 Announce Type: replace Abstract: Rare disease diagnosis depends on expert reasoning that is scarce and difficult to transfer. Large language models rank the correct disease first i...

By Minh-Ha Nguyen, Erica Gray, Bryce A. Schuler, Kevin W. Byram, Chih-Ting Yang, Fan Ma, Hua Xu, Wu-Chen Su, Chao Yan, Wei-Qi Wei, Adam Wright, Lisa Bastarache, Josh F. Peterson, Lingyao Li, Siyuan Ma, Undiagnosed Diseases Network, Rizwan Hamid, Thomas A. Cassini, Cathy Shyr
arXiv Computation and Language
Sep 4

Gaokerena: A Small Persian Medical Language Model Family

Gaokerena is a family of compact Persian medical language models designed for consumer‑grade hardware. The first variant, Gaokerena‑V, was trained on a 90‑million‑token Persian medical corpus and 20,000 physician Q&A pairs, raising a translated medical MMLU benchmark score from 46.28% to 49.31%. A second variant, Gaokerena‑R, adds a Chain‑of‑Thought approach and two Reinforcement Learning with AI Feedback frameworks, achieving a higher benchmark score of 52.98% while also providing uncertainty estimates based on internal hidden states.

By Mehrdad Ghassabi, Hamidreza Baradaran Kashani, Pedram Rostami, Sadra Hakim, Zahra Kazemi, Amirhossein Poursina, Milad Tavakoli, Audrina Ebrahimi