arXiv Machine Learning

Modular Expert Merging for Biomedical Retrieval

The paper proposes a method called Modular Expert Merging for Biomedical Retrieval, which combines independently trained domain‑specialized experts instead of large mixed‑domain training. Experiments across four decoder‑only LLM families (0.6B‑7B) and twelve retrieval tasks from MTEB show that merging experts consistently outperforms mixed‑domain training. The authors also introduce a Synthesize‑Train‑Merge (STM) framework that generates hard negatives with a top‑tier LLM, fine‑tunes experts via LoRA, and merges them, achieving strong biomedical retrieval performance while retaining competitive general‑domain results.

arXiv AI
Sep 17

Generalist-Specialist Mixture-of-Experts for Rare Pathology Detection in Multimodal Imaging

The paper introduces Generalist‑Specialist Mixture‑of‑Experts (GS‑MoE), a two‑branch architecture that combines a cross‑modal generalist model with modality‑specific specialists through domain‑constrained feature fusion. GS‑MoE improves detection of rare pathologies in multimodal medical imaging, achieving significant per‑class F1 gains and outperforming dense and specialist‑only MoE baselines while using about 53% fewer active parameters at inference. The study demonstrates that balancing cross‑modal shared representations with expert routing can enhance performance on low‑prevalence conditions.

By Johannes Kaiser, Florian Braunmiller, Daniel R\"uckert, Georgios Kaissis
arXiv Machine Learning
Aug 3

MoPET: Parameter-Efficient Mixture-of-Experts for Unified Medical Image Classification

arXiv:2607. 29462v1 Announce Type: cross Abstract: Adapting deep learning models to profound clinical heterogeneity typically relies on parameter-efficient fine-tuning (PEFT) to avoid the severe overfitting associated with full end-to-end network updates.

By Sebastian Doerrich, Daniel W\"urtinger, Francesco Di Salvo, Shyam Nandan Rai, Christian Ledig
arXiv Computer Vision
2d ago

Harnessing Domain Specialists in Multimodal Mixture-of-Experts for Efficient Adaptation

The paper investigates whether the sparsity of Mixture-of-Experts (MoE) models leads to intrinsic semantic organization across modalities and domains. It shows that experts naturally specialize semantically even without explicit modular training. The authors propose ExpertLens, a data‑free method that decodes router weights to identify domain‑specialized experts, enabling selective fine‑tuning that matches or exceeds full fine‑tuning while updating only 21.7–47.0% of parameters and achieving a 4.0× speedup, outperforming LoRA in both performance and efficiency.

By Damiano Marsili, Raphi Kang, Aditya Mehta, Pietro Perona, Georgia Gkioxari
arXiv Computation and Language
Sep 4

Distilled Rapid Embedding Transfer (DRET): Parameter-Efficient Biomedical Domain Adaptation via Priority-Based Embedding Transfer

The paper introduces Distilled Rapid Embedding Transfer (DRET), a parameter‑efficient method that injects biomedical domain knowledge from large specialized models into a smaller general‑purpose model without retraining on the original specialized corpora. DRET evolves through iterative strategies—tokenizer‑merge (DRET 1.x), hybrid embedding averaging (DRET 2.0), priority‑based embedding transfer (DRET 3.x), and further refinements (DRET 4.x)—and demonstrates that a 66‑million‑parameter DistilBERT can achieve competitive or superior performance on token‑level PICO classification compared to much larger models, while remaining lightweight. The authors validate the embedding‑level transfer with cosine similarity, semantic‑shift, and t‑SNE analyses, highlighting DRET’s potential for scalable, resource‑efficient biomedical text mining.

By Girish Sundaram, Daniel Berleant
arXiv Computation and Language
3d ago

Exploring Heterogeneous Model Merging Approach for Complex Knowledge Transfer

The paper investigates transferring specialized task-oriented behavior to a general language model without training or distillation. It applies two training‑free heterogeneous merging techniques—Intersection‑Merge (IM) and Activate‑Prune‑Merge (APM)—to project a specialist donor into the recipient’s parameter space and interpolate backbone weights. Experiments across embedding, reranking, reward modeling, and MoE code‑specialist tasks show that both methods improve the general model, demonstrating that simple parameter‑level merging can transfer capabilities across diverse specialist roles.

By Jiahe Fan, Si Chen, Yinghao Hou, Wenbo Xia, Ke Xu, Hong Xie, Enhong Chen
arXiv AI
Jul 2

RareDxR1: Autonomous Medical Reasoning for Rare Disease Diagnosis Beyond Human Annotation

arXiv:2607. 00147v1 Announce Type: new Abstract: Rare disease differential diagnosis is a critical yet arduous clinical task, requiring physicians to identify precise phenotypes from complex, unstructured patient symptoms and execute intricate reasoning within a vast search space.

By Deyang Jiang, Haoran Wu, Ziyi Wang, Yiming Rong, Yunlong Zhao, Ye Jin, Bo Xu