arXiv Machine Learning

Generalized Biomedicine Discovery

The paper introduces Generalized Biomedicine Discovery (GBD), a benchmark that addresses long‑tail, anomaly, and taxonomy‑aware discovery in medical imaging. It proposes SCAN, a cognition‑inspired method that suppresses expected patterns, highlights surprising deviations, and integrates these into global representations. Experiments demonstrate that SCAN enhances novel concept discovery while preserving established clinical knowledge and can be integrated into existing architectures.

arXiv Computer Vision
Sep 21

Graph-Augmented Topological Internalization with Dual-Stream Classifiers for Medical Report Generation

The paper introduces GDMRG, a Graph-Augmented Dual-Stream Medical Report Generation framework that incorporates a Topological Knowledge Internalization module using a Graph Convolutional Network to encode disease co-occurrence priors. It employs a dual-stream classifier—one branch generating diagnostic prompts under topological constraints and an auxiliary branch dynamically calibrating decision boundaries for imbalanced samples—alongside a Diagnosis-Guided Spatial Attention mechanism to align visual features with clinical semantics. Experiments on MIMIC-CXR show competitive clinical efficacy and natural language fluency, with strong zero-shot performance on IU X-Ray.

By Moyu Tang, Shangkun Sima, Chupei Tang, Junxiao Kong, Di Wang, Tianchi Lu
arXiv Computer Vision
Sep 3

Seeing Beyond the Lesion: Disease Recognition from Reactive CNS Tissue

The study evaluates whether disease can be identified from reactive, non‑lesional brain tissue in intracranial biopsies. Using four foundation‑model encoders within an attention‑based multiple‑instance learning framework on 245 whole‑slide images, the authors find that disease labels remain predictive even after controlling for slide size and sampling bias, and that performance is similar across all encoders. Signed instance‑contribution maps and expert review confirm that predictive signals localize to reactive parenchyma rather than artifacts such as blood. "whyItMatters":"The findings demonstrate that weakly supervised models can recover disease signals from tissue traditionally considered non‑diagnostic, highlighting the need for provenance‑only baselines in computational pathology benchmarks."

By Jan Schnorrenberg, Jan Ernsting, Enrico K\"ullenberg, Tim Hahn, Benjamin Risse, Christian Thomas
arXiv Machine Learning
Aug 11

C$^2$A: Coupling Spatial Evidence with Clinical Priors via Co-occurrence Aware Class Attention for Multi-Label Chest X-Ray Classification

arXiv:2608. 09774v1 Announce Type: cross Abstract: Thoracic pathologies rarely occur in isolation, yet standard multi-label classifiers rely on shared global descriptors, discarding \emph{where} findings lie and \emph{how} they co-occur.

By Akash Gogineni, Nagur Shareef Shaik, Aasrith Mandava, Adnan Masood, Dong Hye Ye
arXiv AI
Sep 15

Discovering Hierarchy-Grounded Domains with Adaptive Granularity for Clinical Domain Generalization

The paper introduces UdonCare, a hierarchy‑pruning method that iteratively partitions patients into latent domains using medical ontologies, aiming to improve domain generalization in clinical prediction tasks. It addresses challenges of missing domain labels and lack of clinical insight by discovering hierarchy‑grounded patient domains. Experiments on MIMIC‑III, MIMIC‑IV, and eICU datasets show UdonCare outperforms eight baseline methods across four prediction tasks with significant domain gaps.

By Pengfei Hu, Xiaoxue Han, Fei Wang, Yue Ning
Hugging Face Trending Papers
Sep 2

Seeing Beyond the Lesion: Disease Recognition from Reactive CNS Tissue

The study evaluates whether disease can be identified from reactive, non‑lesional brain tissue in intracranial biopsies. Using four foundation‑model encoders as frozen patch encoders within an attention‑based multiple‑instance learning framework, the authors benchmark performance on 245 whole‑slide images from 186 patients. They find that coarse disease‑category prediction can be largely explained by slide size, but finer diagnostic distinctions remain predictive above chance, with no significant difference among the encoders, suggesting weak morphological signals can be recovered even from tissue traditionally considered non‑diagnostic.