The paper introduces MEGA-CDP, a benchmark designed to evaluate medical large language models (LLMs) on their ability to generate clinical decision pathways (CDPs) that adhere to clinical practice guidelines. MEGA-CDP is built from 2,274 English and Chinese guidelines, producing 42,353 clinical cases with explicit reference CDPs, and supports both single-turn and multi-turn interactions. Experiments on 16 LLMs reveal that reliable guideline adherence remains difficult, underscoring the need for CDP-focused evaluation and the potential of MEGA-CDP to advance medical LLM performance.
arXiv:2604.26766v2 Announce Type: replace-cross Abstract: Accurate and consistent Emergency Severity Index (ESI) assignment remains a persistent challenge in emergency departments, where highly varia...
arXiv:2609.14819v1 Announce Type: cross Abstract: Large language models (LLMs) have a growing range of applications in medicine, and their evaluation is critical for ensuring they provide benefit and...
arXiv:2608.30022v1 Announce Type: new Abstract: Introduction: NICE guidelines provide evidence-based recommendations for clinical care but remain largely in unstructured natural language. Existing ap...
arXiv:2607. 13036v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly used for decision support in healthcare, but clinical evidence is often incomplete or evolving.
arXiv:2606. 03157v1 Announce Type: new Abstract: Large language models (LLMs) have been widely adopted in healthcare, yet they still encounter significant challenges in complex clinical decision-making scenarios.
The paper introduces a benchmark of over 6,000 clinical triage scenarios, 7,000 physician annotations, and 225,000 large language model (LLM) responses to assess how LLMs perform under realistic variations in clinical text. The study finds that LLMs tend to recommend unnecessary care more often than physicians, especially when the input text is perturbed, and that LLM recommendations are more sensitive to gender and tone changes than human recommendations. These findings underscore the importance of deployment‑oriented evaluations that reflect expert physician behavior.
The paper introduces three interpretable metrics—Explanation Stability Index (ESI), Causal Faithfulness Score (CFS), and Perturbation Stability Score (PSS)—to assess the faithfulness of large language models (LLMs) in clinical decision support. Evaluating six LLMs on 150 MedQA-USMLE questions, the study finds that only 23.3% of cited clinical concepts are causally necessary, and that correct answers often have lower CFS than incorrect ones, with answer consistency negatively predicting faithfulness. These findings suggest that accuracy, consistency, and consensus are incomplete safety signals for clinical decision-making support.
The paper introduces a retrieval‑augmented multi‑agent framework that automatically generates instance‑specific evaluation rubrics for medical language models. By retrieving authoritative medical evidence, decomposing it into atomic facts, and combining these with user interaction constraints, the system produces fine‑grained criteria that outperform GPT‑4o on HealthBench and LLMEval‑Med. The generated rubrics also guide response refinement, improving medical LLM output quality by 9.2%.
arXiv:2609.17544v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly being explored for clinical applications, yet their assessment for real-world traditional Chinese medicin...
The paper investigates how medical large language models (LLMs) may exhibit narrative anchoring bias when presented with the same clinical case in different patient voices. Using the NarrativeShield SDoH MedQA dataset, the authors evaluate three Qwen2.5 instruction‑tuned LLMs (1.5B, 3B, 7B) on 300 clinical cases, reporting metrics such as persona‑level accuracy, counterfactual consistency, correct consistency, and narrative sensitivity error. The 7B model achieves the highest accuracy (56.33 %) and correct consistency (40.33 %), yet narrative sensitivity errors remain substantial (31.67 %).
arXiv:2608.28592v1 Announce Type: new Abstract: Large language models (LLMs) achieve high scores on medical knowledge examinations, yet real-world oncology is not a knowledge test--it is a sequence o...
arXiv:2607. 08602v1 Announce Type: new Abstract: Hepatocellular carcinoma (HCC) is a common malignancy and a leading cause of cancer-related mortality.