arXiv AI

Sense and Sensitivity: Benchmarking LLM Clinical Triage Recommendations with Physician Experts

The paper introduces a benchmark of over 6,000 clinical triage scenarios, 7,000 physician annotations, and 225,000 large language model (LLM) responses to assess how LLMs perform under realistic variations in clinical text. The study finds that LLMs tend to recommend unnecessary care more often than physicians, especially when the input text is perturbed, and that LLM recommendations are more sensitive to gender and tone changes than human recommendations. These findings underscore the importance of deployment‑oriented evaluations that reflect expert physician behavior.

arXiv AI
Sep 15

A primer on evaluation methods for large language models in healthcare

arXiv:2609.14819v1 Announce Type: cross Abstract: Large language models (LLMs) have a growing range of applications in medicine, and their evaluation is critical for ensuring they provide benefit and...

By Suzannah E McKinney, Phuc Vu, Samuel A Justice, Christopher Humphries, Alyssa Pradhan, Timothy J Keyes, Bernardo C Bizzo, Keith J Dreyer, Sarah F Mercaldo, James M Hillis
arXiv AI
Jun 17

First, do NOHARM: towards clinically safe large language models

arXiv:2512. 01241v3 Announce Type: replace-cross Abstract: Large language models (LLMs) are routinely used by physicians and patients for medical advice, yet their clinical safety profiles remain poorly characterized.

By David Wu, Fateme Nateghi Haredasht, Saloni Kumar Maharaj, Priyank Jain, Jessica Tran, Matthew Gwiazdon, Arjun Rustagi, Jenelle Jindal, Jacob M. Koshy, Vinay Kadiyala, Anup Agarwal, Bassman Tappuni, Brianna French, Sirus Jesudasen, Christopher V. Cosgriff, Rebanta Chakraborty, Jillian Caldwell, Susan Ziolkowski, David J. Iberri, Robert Diep, Rahul S. Dalal, Kira L. Newman, Kristin Galetta, J. Carl Pallais, Nancy Wei, Kathleen M. Buchheit, David I. Hong, Vartan Pahalyants, Ernest Y. Lee, Allen Shih, Tamara B. Kaplan, Vishnu Ravi, Sarita Khemani, Thomas A. Buckley, April S. Liang, Daniel Shirvani, Advait Patil, Nicholas Marshall, Kanav Chopra, Joel Koh, Adi Badhwar, Anastasia Perez, Austin J. Schoeffler, Mahbuba Tusty, Chase M. Walton, Liam G. McCoy, David J. H. Wu, Yingjie Weng, Sumant Ranji, Kevin Schulman, Nigam H. Shah, Jason Hom, Arnold Milstein, Arjun K. Manrai, Adam Rodman, Jonathan H. Chen, Ethan Goh
arXiv AI
2d ago

Scaling Clinical Judgment to Evaluate Medical AI

arXiv:2609.12822v2 Announce Type: replace Abstract: Blinded physician evaluation has been considered by many to be the gold standard for assessing clinical reasoning in large language models (LLMs)....

By Thomas A. Buckley, Zahir Kanjee, Peter G. Brodeur, Byron Crowe, Anthony M. Pettinato, Aashna P. Shah, Adrian D. Haimovich, Liam G. McCoy, Daniel Restrepo, Jason A. Freed, Ethan Goh, Jonathan H. Chen, Laura Zwaan, Katherine E. Goodman, Daniel J. Morgan, Raja-Elie E. Abdulnour, Adam Rodman, Arjun K. Manrai
arXiv AI
Jun 2

Understanding Stigmatizing Language in Clinical Documentation: A Paired Comparison of Ambient AI Drafts and Clinician Finalized Notes

arXiv:2606. 00019v1 Announce Type: cross Abstract: Ambient artificial intelligence (AI) documentation tools are increasingly deployed to reduce clinician documentation burden, but their implications for biased language in clinical notes remain unclear.

By Yiliang Zhou, Yawen Guo, Sairam Sutari, Jasmine Dhillon, Alexandra L. Beck, Emilie Chow, Steven Tam, Danielle Perret, Deepti Pandita, Gelareh Sadigh, Archana J. McEligot, Kai Zheng
arXiv AI
Sep 4

MIRA: A Bilingual Benchmark for Medical Information Response Audit

MIRA is a bilingual benchmark that evaluates whether large language models (LLMs) provide consistent medical information across different user phrasings, languages, and health literacy levels. It contains 4,320 prompts derived from 60 medically reviewed low‑risk health questions and reveals that models tend to omit key information and offer fewer concrete next steps when responding to low health‑literacy signals, a phenomenon termed Differential Information Dilution (DID). A knowledge‑guided mitigation prompt can reduce this dilution for most models, notably improving Claude and Qwen.

By Mengyu Xu, Qiaoxin Yang, Qianqian Wang, Xiwei Dai, Weiyi Wu, Chongyang Gao
arXiv Computation and Language
Aug 28

Benchmarking Clinical Decision Pathway Adherence in Large Language Models

The paper introduces MEGA-CDP, a benchmark designed to evaluate medical large language models (LLMs) on their ability to generate clinical decision pathways (CDPs) that adhere to clinical practice guidelines. MEGA-CDP is built from 2,274 English and Chinese guidelines, producing 42,353 clinical cases with explicit reference CDPs, and supports both single-turn and multi-turn interactions. Experiments on 16 LLMs reveal that reliable guideline adherence remains difficult, underscoring the need for CDP-focused evaluation and the potential of MEGA-CDP to advance medical LLM performance.

By Nuo Chen, Xinyang Jiang, Zilong Wang, Zhifei Zhang, Xiaoye Qu, Jiajun Deng, Yulan Guo, Cairong Zhao
arXiv AI
Aug 12

Locally Deployable Small Language Models for Emergency Department Decision Support: A Systematic Benchmark of Fine-Tuning Strategies

arXiv:2608. 10273v1 Announce Type: cross Abstract: Deploying large language models (LLMs) for decision support in emergency departments (EDs) faces two major challenges: privacy risks of transmitting patient data to closed-source commercial LLMs and the lack of systematic evaluation of fine-tuning strategies for locally deployable open-source small language models (SLMs).

By Qingfeng Zhang, Yuanxiong Guo, Yanmin Gong