arXiv AI

A primer on evaluation methods for large language models in healthcare

arXiv Computation and Language
5d ago

LLJ Cards: Best practices for the Use of LLMs as Judges

arXiv:2609.24516v1 Announce Type: new Abstract: In recent years, large language models (LLMs) have emerged as a popular alternative for evaluation. Often referred to as LLMs as judges (LLJs), these s...

By Khaoula Chehbouni, Melina Medjdoub, Florian Carichon, Golnoosh Farnadi, Jackie Chi Kit Cheung
arXiv AI
Aug 28

Evaluating AI Generated Summaries for Cancer Patients

The study evaluates AI-generated summaries for cancer patients using a dual assessment framework that includes human experts and LLM-as-a-judge. Human domain experts—oncology clinicians and patient-facing care staff—assess summary quality on accuracy, clinical relevance, and readability. The research identifies limitations such as omissions and minor inaccuracies, which are then used to iteratively refine prompts, grounding, and safety guardrails.

By Muhammad Aurangzeb Ahmad, Kim Shyu, Leon Oliver, Fergus Sleight, Paul Landau
arXiv AI
Jul 22

MEDIC: Comprehensive Evaluation of Leading Indicators for LLM Safety and Utility in Clinical Applications

arXiv:2409. 07314v3 Announce Type: replace-cross Abstract: While Large Language Models (LLMs) achieve superhuman performance on standardized medical licensing exams, these static benchmarks have become saturated and increasingly disconnected from the functional requirements of clinical workflows.

By Praveenkumar Kanithi, Cl\'ement Christophe, Marco AF Pimentel, Tathagata Raha, Prateek Munjal, Nada Saadi, Hamza A Javed, Svetlana Maslenkova, Nasir Hayat, Ronnie Rajan, Shadab Khan
arXiv Computation and Language
Aug 27

Retrieval-Augmented Agentic Rubric Generation for Reliable Medical Response Evaluation

The paper introduces a retrieval‑augmented multi‑agent framework that automatically generates instance‑specific evaluation rubrics for medical language models. By retrieving authoritative medical evidence, decomposing it into atomic facts, and combining these with user interaction constraints, the system produces fine‑grained criteria that outperform GPT‑4o on HealthBench and LLMEval‑Med. The generated rubrics also guide response refinement, improving medical LLM output quality by 9.2%.

By Yinzhu Chen, Abdine Maiga, Hossein A. Rahmani, Emine Yilmaz
arXiv Computation and Language
Aug 27

MTDiag: A Multi-Turn Diagnostic Dataset Towards Clinically Meaningful LLM Evaluation

MTDiag is a newly released multi-turn diagnostic dialogue dataset designed to evaluate large language models (LLMs) in clinically meaningful ways. It is built from DDXPlus, MIMIC-IV, and AJCR case reports, covering both common emergency department presentations and rare conditions, and normalizes cases into a canonical schema using UMLS concept identifiers and ICD-10 codes. The dataset includes a UserLM‑8B utterance‑generation pipeline and physician‑validated natural‑language utterances, and introduces clinical knowledge‑grounded metrics that go beyond simple diagnostic accuracy for multi‑turn differential diagnosis tasks.

By Pia Chouayfati, Alexander M. Fichtl, Miriam Ansch\"utz, George Doumat, Georg Groh
arXiv AI
Jun 2

A Multi-Domain Red Teaming Framework for Safety, Robustness, and Fairness Evaluation of Medical Large Language Models

arXiv:2606. 00027v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly deployed across healthcare, yet existing benchmarks fail to capture model behavior under adversarial or ethically complex conditions common in clinical practice.

By Andrei Marian Feier, Veysel Kocaman, Yigit Gul, Ahmet Korkmaz, Alexander Thomas, Aleksei Zakharov, Jay Gil, Mehmet Butgul, David Talby
arXiv AI
Jul 28

OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries

arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.

By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv Computation and Language
Aug 28

Benchmarking Clinical Decision Pathway Adherence in Large Language Models

The paper introduces MEGA-CDP, a benchmark designed to evaluate medical large language models (LLMs) on their ability to generate clinical decision pathways (CDPs) that adhere to clinical practice guidelines. MEGA-CDP is built from 2,274 English and Chinese guidelines, producing 42,353 clinical cases with explicit reference CDPs, and supports both single-turn and multi-turn interactions. Experiments on 16 LLMs reveal that reliable guideline adherence remains difficult, underscoring the need for CDP-focused evaluation and the potential of MEGA-CDP to advance medical LLM performance.

By Nuo Chen, Xinyang Jiang, Zilong Wang, Zhifei Zhang, Xiaoye Qu, Jiajun Deng, Yulan Guo, Cairong Zhao