arXiv AI

OmniVCBench: Benchmarking Evidence-Grounded Multimodal Reasoning Towards AI Virtual Cells

OmniVCBench is a figure‑centric, source‑traceable benchmark designed to evaluate the interpretation component of Artificial Intelligence Virtual Cells (AIVCs). It comprises 6,077 curated question–answer pairs drawn from scientific figures and experimental contexts, organized into three scientific reasoning tasks that mirror the AIVC Predict–Explain–Discover agenda. The benchmark also introduces AIVC‑Judge, a task‑conditioned MLLM‑as‑a‑judge framework with reference‑aware rubrics, and a Model‑Derived Hard‑Negative Mining strategy to generate multiple‑choice distractors for efficient evaluation.

arXiv AI
Sep 12

Sci-MMR: Benchmarking Multi-Step Evidence-Grounded Scientific Reasoning in Multimodal Agents

Sci‑MMR is a new benchmark for multi‑step evidence‑grounded scientific reasoning in multimodal agents, featuring 235 multi‑hop tasks across four disciplines and an average of nine figure panels per task. It evaluates not just final answer accuracy but also the recovery of structured evidence from scientific claims, citations, visual data, and supporting regions. Experiments on eight state‑of‑the‑art models show a gap of over 20 points between answer accuracy and complete evidence recovery, highlighting significant challenges in evidence acquisition and integration.

By Jiaqiang Li, Yajie Yang, Zhiheng Xi, Jiadong Chen, Enyu Zhou, Senjie Jin, Yang Nan, Jiazheng Zhang, Han Wang, Yanxin Li, Dingwei Zhu, Bicheng Deng, Yuhui Wang, Xiang Zheng, Qi Zhang, Lei Bai, Xingjun Ma, Tao Gui
arXiv Machine Learning
Sep 22

Tool-Augmented On-Policy Distillation for LLM Domain Adaptation in Sequence-Based Omics Tasks

The paper introduces OmicsBench, a new reasoning benchmark for multi‑omics sequences that includes 1,160 expert‑validated questions across DNA regulation, RNA processing, and protein function tasks, requiring traceable evidence chains. Evaluation of 17 large language models shows that scientific LLMs, while more accurate in classification, often lack valid evidence, suggesting shortcut learning. To address this, the authors propose tool‑augmented on‑policy distillation (TA‑OPD), a post‑training method that improves both evidence grounding and predictive performance across five Qwen3.5 models of varying sizes.

By Jie Ying, Zhefan Wang, Zihong Chen, Zhengqing Li, Jinzhe Li, Gang Li, Jian Liu, Fang Hu, Tao Luo, Zhonghang Yuan, Wanli Ouyang, Stan Z. Li, Fan Yang, Nanqing Dong
arXiv AI
Sep 18

BioPhys-Bridge: A Benchmark for Interdisciplinary Scientific Reasoning in Physics-Grounded Biological Research

BioPhys-Bridge is a newly released benchmark dataset designed to evaluate language models on evidence‑grounded scientific reasoning within biophysical literature. Each of its 500 cases includes evidence blocks, stable IDs, quantitative values, units, equations, assumptions, mechanisms, and next‑step decisions, covering six biological domains and nine physical model families. The dataset enforces strict quality gates and has already been evaluated against several models, with DeepSeek‑V4‑Flash achieving the highest evidence‑ID F1 score of 0.360.

By Qingyang Xu
arXiv AI
Jun 11

OpenMedReason: Scientific Reasoning Supervision for Medical Vision-Language Models

arXiv:2606. 12169v1 Announce Type: cross Abstract: High-stakes clinical use of large vision-language models (LVLMs) requires reasoning that is grounded in visual evidence and clinical knowledge, not just correct final answers.

By Negin Baghbanzadeh, Pritam Sarkar, Michael Colacci, Abeer Badawi, Adibvafa Fallahpour, Arash Afkanpour, Leonid Sigal, Ali Etemad, Elham Dolatabadi
arXiv AI
Jul 20

S1-Omni: A Unified Multimodal Reasoning Model for Scientific Understanding, Prediction, and Generation

arXiv:2607. 15686v1 Announce Type: new Abstract: We present S1-Omni, a unified multimodal reasoning model for scientific understanding, prediction, and generation.

By Jiahao Zhao, Junyi Liu, Lifeng Xu, Nan Xu, Qingli Wang, Qingxiao Li, Tianle Chen, Xiaoyu Wu, Yawen Zheng, Zikai Wang, Guanming Liu, Hequn Zhou, Jingyi Wang, Jingyuan Shu, Keqi Wang, Li He, Songyang Diao, Wenhui Xu, Xinyu Ren, Yaqin Fan, Yujin Zhou, Zhanao Yao
arXiv AI
Aug 17

A Pathway to General-Purpose Scientific AI: Multimodal Comprehension of Scientific Images

arXiv:2608. 14075v1 Announce Type: new Abstract: Scientific figures and tables encode essential experimental evidence, yet remain difficult for digital libraries and multimodal AI systems to retrieve and interpret.

By Jennifer D'Souza, Fahad Ahmed, Cecilia Andrea Bustamante Andrade, Lina Frolova, Poorani Gnanasambandan, Dilshad Hussain, Muhammad Uzair Khan, Nkembeng Kevin Nkengfoa, Paul Praveen J., Fabio Priante, Sjoerd Franciscus van der Werf, Thomas Frederik Jan van Roeden
arXiv Computer Vision
2d ago

SciGen-Verifier: A Multimodal Reasoner for Explainable Verification in Scientific Image Generation

arXiv:2609.33399v2 Announce Type: replace Abstract: In realistic education, a solution is often expressed not only in words but in a drawing--a circuit, a geometric construction, a function plot--and...

By Jiali Chen, Zhengteng Lin, Zuqi Wang, Shirong Lin, Xi Yu, Xusen Hei, DingBa Fu, Jiayuan Xie, Yi Cai
arXiv AI
4d ago

BioEVAL: A global, multi-institutional benchmark of large language and multimodal models for bioengineering

BioEVAL is a global, multi‑institutional benchmark that evaluates large language and multimodal models on experimental reasoning tasks in bioengineering. It comprises 608 items across 11 bioengineering subfields, including 359 vetted multiple‑choice questions, 218 literature synthesis tasks, and 10 multimodal image‑interpretation problems. The benchmark was used to assess models such as ChatGPT, Gemini, and Grok, revealing accuracies up to 90% on MCQs, a 0.72 similarity score on literature synthesis, and 80% accuracy on multimodal tasks, with notable variation across subfields.

By Shun Ye, Vinny Chandran Suja, Chenlong Li, Chongming Jiang, Reza Zamani, Xiang Li, Christopher Bain, Yuqi Zhou, Walker Peterson, Huidong Wang, Chenglang Hu, Jongchan Park, Xiao Cheng, Benjamin Swedlund, Sandra Murillo, Anjali Sivanandan, Shiyu Sun, Liang Lanfeng, Mohammad Tariqul Islam, Baju C. Joy, Ishaq N. Khan, Sreedhar S. Kumar, Gabriel Mercado-V\'asquez, James V. Vizzard, Jonathan M. Matthews, Helen Huang, Xiaolu Guo, Ethan Nicklow, Guorui Chen, Ryan A. Neff, Surjendu Maity, Hyeonjin Park, Han-ho Joo, Katherine Dong, Yuyan Cai, Weihang Huang, Yichen Zou, Rui Yan, Raphael Figueroa, Artem Goncharov, Bella Rose Schremmer, Lian Elsa Linton, Keisuke Goda, Liang Gao, Ke Cheng, Leonardo Morsut, Jennifer L. Wilson, Jianping Fu, Lim Chwee Teck, Deblina Sarkar, Andreas Hierlemann, Sava\c{s} Tay, Alexander Hoffmann, Donald Richieri Griffin, Jun Chen, Shana O. Kelley, Shyni Varghese, Jinwoo Cheon, Wilbur A. Lam, James J. Moon, Wilson W. Wong, Samir Mitragotri, Dino Di Carlo