arXiv AI

BioPhys-Bridge: A Benchmark for Interdisciplinary Scientific Reasoning in Physics-Grounded Biological Research

BioPhys-Bridge is a newly released benchmark dataset designed to evaluate language models on evidence‑grounded scientific reasoning within biophysical literature. Each of its 500 cases includes evidence blocks, stable IDs, quantitative values, units, equations, assumptions, mechanisms, and next‑step decisions, covering six biological domains and nine physical model families. The dataset enforces strict quality gates and has already been evaluated against several models, with DeepSeek‑V4‑Flash achieving the highest evidence‑ID F1 score of 0.360.

arXiv AI
Sep 12

Sci-MMR: Benchmarking Multi-Step Evidence-Grounded Scientific Reasoning in Multimodal Agents

Sci‑MMR is a new benchmark for multi‑step evidence‑grounded scientific reasoning in multimodal agents, featuring 235 multi‑hop tasks across four disciplines and an average of nine figure panels per task. It evaluates not just final answer accuracy but also the recovery of structured evidence from scientific claims, citations, visual data, and supporting regions. Experiments on eight state‑of‑the‑art models show a gap of over 20 points between answer accuracy and complete evidence recovery, highlighting significant challenges in evidence acquisition and integration.

By Jiaqiang Li, Yajie Yang, Zhiheng Xi, Jiadong Chen, Enyu Zhou, Senjie Jin, Yang Nan, Jiazheng Zhang, Han Wang, Yanxin Li, Dingwei Zhu, Bicheng Deng, Yuhui Wang, Xiang Zheng, Qi Zhang, Lei Bai, Xingjun Ma, Tao Gui
arXiv Machine Learning
1d ago

Tool-Augmented On-Policy Distillation for LLM Domain Adaptation in Sequence-Based Omics Tasks

The paper introduces OmicsBench, a new reasoning benchmark for multi‑omics sequences that includes 1,160 expert‑validated questions across DNA regulation, RNA processing, and protein function tasks, requiring traceable evidence chains. Evaluation of 17 large language models shows that scientific LLMs, while more accurate in classification, often lack valid evidence, suggesting shortcut learning. To address this, the authors propose tool‑augmented on‑policy distillation (TA‑OPD), a post‑training method that improves both evidence grounding and predictive performance across five Qwen3.5 models of varying sizes.

By Jie Ying, Zhefan Wang, Zihong Chen, Zhengqing Li, Jinzhe Li, Gang Li, Jian Liu, Fang Hu, Tao Luo, Zhonghang Yuan, Wanli Ouyang, Stan Z. Li, Fan Yang, Nanqing Dong
arXiv AI
Aug 26

Generating Biomedical Fact-Checking Reports with RL-Enhanced Agentic Search

The paper introduces BioCheck Agent, an LLM-based system that generates structured biomedical fact‑checking reports using agentic search and a reinforcement‑learning framework called EG‑GRPO. Unlike prior methods that output only supported or refuted labels, BioCheck Agent synthesizes conclusions with retrieved evidence from PubMed, employing advanced Boolean search operators. Experiments show that, compared to the base Qwen3.5‑4B model, BioCheck Agent improves label prediction accuracy on SciFact by 9.95 %, raises evidence quality by 3.7 %, and reduces hallucinations by 19.63 %.

By Jiongxiao Wang, Dingli Ma, Chaoqun Ni
arXiv Machine Learning
Jun 5

SUPERNOVA: Eliciting General Reasoning in LLMs with Reinforcement Learning on Natural Instructions

arXiv:2604. 08477v2 Announce Type: replace-cross Abstract: Reinforcement Learning with Verifiable Rewards (RLVR) has substantially improved reasoning in formal domains such as mathematics and code, but extending these gains beyond STEM remains challenging.

By Ashima Suvarna, Kendrick Phan, Mehrab Beikzadeh, Hritik Bansal, Saadia Gabriel
arXiv AI
Jun 12

Benchmarking AI Agents for Addressing Scientific Challenges Across Scales

arXiv:2606. 12736v1 Announce Type: new Abstract: AI agents are increasingly being developed to accelerate scientific discovery, yet their practical capabilities in real research settings remain poorly understood.

By Tianyu Liu, Allen Xin Wang, Antonia Panescu, Lisa Xinyi Chen, Wenxin Long, Xinyu Wei, Yueqian Jing, Ziyao Zeng, Jihang Chen, Sihan Jiang, Ziqing Wang, Siyi Gu, Siyu Chen, Xinyang Hu, Haoran Shao, Leqi Xu, Wangjie Zheng, Zhiyuan Cao, Ada Fang, Botao Yu, Kunyang Sun, Rex Ying, Arman Cohan, Qingyu Chen, Lingzhou Xue, Kaize Ding, Yuanqi Du, Wengong Jin, Zhuoran Yang, Marinka Zitnik, James Zou, Hua Xu, Hongyu Zhao