arXiv AI

Diffusion Model in Latent Space for Medical Image Segmentation Task

The paper introduces MedSegLatDiff, a diffusion-based framework that combines a variational autoencoder (VAE) with a latent diffusion model for medical image segmentation. By compressing images into a low-dimensional latent space, the method reduces noise and speeds up training, while a weighted cross‑entropy loss preserves tiny structures such as small nodules. Evaluated on ISIC‑2018, CVC‑Clinic, and LIDC‑IDRI datasets, MedSegLatDiff achieves state‑of‑the‑art Dice and IoU scores, generates diverse segmentation hypotheses, and produces confidence maps that enhance interpretability and reliability for clinical deployment.

arXiv Computer Vision
4d ago

MedDiME: Efficient Latent Diffusion with Adaptive Masking for Medical Counterfactual Generation

MedDiME is a latent-space, classifier‑guided diffusion framework designed for medical counterfactual image generation. It introduces a gradient‑driven adaptive masking mechanism that works directly in latent space, enabling spatially precise edits while avoiding the high computational and memory costs of pixel‑space methods. Experiments show MedDiME can produce high‑quality counterfactuals up to 40× faster and using 13× less GPU memory than previous diffusion baselines.

By Yan Zeng, Changlu Guo, Anders Nymark Christensen, Morten Rieger Hannemose, Anders Bjorholm Dahl
arXiv AI
Sep 3

InstEditSeg: Instruction-Driven Image Editing for Polyp and Skin Lesion Segmentation

InstEditSeg is a generative framework that treats medical segmentation as an instruction-driven image editing task. Instead of producing binary masks, it renders a color-coded overlay on the original image guided by textual instructions, leveraging latent diffusion models to align with natural image distributions and reduce domain gaps. The method incorporates a DINOv3 visual encoder and a multi-scale feature pyramid fused into the diffusion U‑Net, and uses a dual‑branch classifier‑free guidance strategy to lower inference cost, achieving competitive accuracy on polyp and skin lesion datasets while improving cross‑domain generalization and multi‑lesion segmentation.

By Ziquan Liu, Zhewei Zhu, Xuyang Shi
arXiv Machine Learning
Aug 27

Unsupervised Anatomical Feature Learning via Diffusion Models: Enhanced Medical Image Segmentation with Denoising Diffusion Probabilistic Models

The paper introduces an unsupervised approach to medical image segmentation by training a Denoising Diffusion Probabilistic Model (DDPM) on 21 unlabeled abdominal CT scans to learn anatomical features. The encoder weights from the DDPM are transferred to a U‑Net for downstream segmentation on the BTCV multi‑organ dataset, resulting in a significant Dice score improvement for liver segmentation from 0.75 to 0.93. In low‑data regimes, diffusion‑pretrained models retain robust performance, achieving high Dice scores even with only 10% of labeled data.

By Akshat G, Divyansh Gupta, Shaleen Bhatnagar, Shilpa Ankalaki, Tusar Kanti Mishra
arXiv AI
Aug 3

DualDiT: A Conditional Dual-Output Diffusion Transformer for Joint OCT Image and Segmentation Mask Generation

arXiv:2607. 29337v1 Announce Type: cross Abstract: Background and Objective: Generating realistic medical images with anatomically accurate segmentation masks helps address the shortage of annotated data in medical imaging, particularly in optical coherence tomography (OCT) of mouse eyes, where manual retinal layer delineation is labour-intensive due to tiny structures and required expertise, resulting in scarce datasets.

By Fernando Garc\'ia-Torres, Roc\'io del Amor, Sandra Morales, \'Alvaro Barroso, Peter Heiduschka, Bj\"orn Kemper, Valery Naranjo
arXiv AI
Jul 8

CONFLUX: A Latent Diffusion Model for 3D Chest-CT Synthesis with RL Post-Training

arXiv:2607. 02998v2 Announce Type: replace-cross Abstract: Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning.

By Max Van Puyvelde, Halil Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert