The paper critiques the common reinforcement‑learning approach of sampling tool subsets when the full set of tools is enumerable, showing that sampling leads to degraded policy estimates and increased reward sparsity in genomic reasoning tasks. It proposes Full‑Group Policy Optimization (FGPO), which evaluates every tool subset and precomputes rewards in a table, thereby eliminating the need for frozen‑reasoner calls during training. Experiments across five frozen reasoners and three genomic benchmarks demonstrate that FGPO consistently outperforms GRPO, improving average scores by 6.75 points and reducing the number of invoked tools per question.
By Haoyue Liu, Xiaoyu Ma, Ye Chen, Zhichao Wang, Xiaoying Tang
arXiv:2606. 16517v1 Announce Type: new Abstract: Scientific reasoning models for biology combine language models with foundation models trained on multimodal biological data, including DNA, RNA, and proteins.
By Lukas Fesser, Hanlin Zhang, Michelle M. Li, Eric Wang, Bryan Perozzi, Shekoofeh Azizi, Sham M. Kakade, Marinka Zitnik
arXiv:2606. 17024v1 Announce Type: new Abstract: Sparse reward reinforcement learning (RL) has become a standard tool for improving LLM reasoning, but its success depends critically on the coverage present in the base model.
By Violet Xiang, Amrith Setlur, Chase Blagden, Nick Haber, Aviral Kumar
arXiv:2607. 16205v1 Announce Type: new Abstract: Reinforcement learning with verifiable rewards has emerged as a standard approach for enhancing reasoning in large language models, which typically optimizes the policy by contrasting multiple self generated rollouts.
By Dayu Wang, Jiaye Yang, Weikang Li, Jiahui Liang, Liwei Qian, Xin Pei, Jizhou Huang
Scientific reasoning models for biology combine language models with foundation models trained on multimodal biological data, including DNA, RNA, and proteins. These models are built through post-training, yet how each stage shapes reasoning and generalization remains poorly understood.
The paper introduces Feedback‑Enriched Environments (FEEs) as a new approach to training large language models as autonomous agents for long‑horizon tasks. By shifting from action guidance to observation enrichment during later stages of exploration, FEEs improve performance across SciWorld and BFCL benchmarks with various Qwen3 model scales and RL algorithms. The study shows that FEEs stabilize training, promote proactive exploration, embed environmental guidance into policy weights, and highlight intra‑group feedback consistency as key for stable optimization.
By Hongbang Yuan, Zhuoran Jin, Yixin Cao
arXiv:2606. 01281v1 Announce Type: cross Abstract: Reinforcement learning with verifiable rewards (RLVR) has emerged as a powerful paradigm for enhancing the reasoning capabilities of large language models (LLMs).
By Yixiu Mao, Yun Qu, Qi Wang, Heming Zou, Xiangyang Ji
arXiv:2609.00189v1 Announce Type: new
Abstract: Goal-directed optimization is essential for steering molecular generators to propose candidates with desired properties. However, it is often implement...
By Shiyun Wa, Yifei Wang, Anna G. Green, Simone Sciabola, Ye Wang
arXiv:2605. 20256v2 Announce Type: replace Abstract: Reinforcement learning has become a cornerstone for aligning and unlocking the reasoning capabilities of large-scale models.
By Xikai Zhang, Yongzhi Li, Likang Xiao, Yingze Zhang, Yanhua Cheng, Quan Chen, Peng Jiang, Wenjun Wu, Liu Liu
Reinforcement learning over a frozen reasoner has become a common recipe for teaching a policy which external tools to invoke. We show that this recipe becomes structurally mismatched in specialist sc...
arXiv:2608.22967v1 Announce Type: new
Abstract: Practical molecular inverse design is rarely a one-shot generation problem; it often takes the form of closed-loop candidate-pool enrichment, where und...
By Yaoyao Xu, Xinjian Zhao, Xiaozhuang Song, Lei Bai, Tianshu Yu
arXiv:2508. 10123v3 Announce Type: replace-cross Abstract: Advanced reasoning in LLMs on challenging domains like mathematical reasoning can be tackled using verifiable rewards based reinforced fine-tuning (ReFT).
By Maxime Heuillet, Yufei Cui, Boxing Chen, Audrey Durand, Prasanna Parthasarathi