The paper presents Copula Adapted Directed Acyclic Graph (CopDAG), a framework that combines copula models with an ensemble of causal structure discovery methods based on Directed Acyclic Graphs to represent biomedical data. By capturing non‑Gaussian, non‑linear dependencies and stable causal relationships, CopDAG enables clustering of unlabeled biomedical data using K‑means. Across 16 biomedical datasets, CopDAG achieves the highest normalized clustering accuracy and adjusted Rand index among 12 evaluated methods, and it can predict class labels and provide explainable causal visualizations without relying on data annotations.
arXiv:2607. 03364v1 Announce Type: cross Abstract: We propose \textbf{CaSPECT}, a causal spectral clustering framework for discovering causally homogeneous subgroups from observational data.
arXiv:2403. 00965v2 Announce Type: replace-cross Abstract: Only a small fraction of patients with chronic kidney disease (CKD) progress to dialysis, creating severe class imbalance that limits the performance of machine learning models for early dialysis prediction.
arXiv:2511. 17605v2 Announce Type: replace Abstract: Clinical and gene-expression models predict breast cancer outcomes, but simple linear fusion ignores dependence between their risk scores.
arXiv:2607. 25020v1 Announce Type: new Abstract: Vine copulas provide a flexible framework for modeling complex multivariate distributions through a hierarchical decomposition into bivariate pair-copulas.
Vine copulas provide a flexible framework for modeling complex multivariate distributions through a hierarchical decomposition into bivariate pair-copulas. Fitting a D-vine requires selecting a copula family and parameter configuration for each pair-copula from a set of candidates encoding different dependence patterns.
arXiv:2607. 03487v1 Announce Type: cross Abstract: Mutual information (MI) estimation is a central problem in machine learning and statistics; however, existing benchmarks typically evaluate estimators on simplified, low-dimensional distributions, leaving their performance on complex, realistic data largely unexplored.
arXiv:2508. 13831v4 Announce Type: replace-cross Abstract: Functional data, i.
The paper introduces Explainable Graph-theoretical Machine Learning (XGML) to build individual metabolic brain graphs from FDG-PET data and identify subgraphs predictive of multivariate Alzheimer’s disease outcomes. Using ADNI data, the best model—kernel density estimation with Hellinger distance and random forest—achieved a Pearson correlation of 0.595 across eight cognitive scores, with the highest performance on ADAS13, ADAS11, and ADASQ4. Key edges were found to be jointly but differentially predictive, indicating potential network biomarkers for cognitive decline, though external validation on OASIS3 showed weaker performance likely due to cohort differences.
arXiv:2608. 06990v1 Announce Type: cross Abstract: Clustering is a fundamental data mining technique for pattern recognition through unsupervised learning.
arXiv:2608. 16029v1 Announce Type: new Abstract: Group Independent Component Analysis (gICA) is widely used to decompose high-dimensional functional MRI data into interpretable brain networks.
arXiv:2606. 31171v1 Announce Type: new Abstract: Acquiring comprehensive cross-domain biomedical profiles is often costly and time-consuming, resulting in severe data scarcity in medical research.
The paper introduces the Relational Hypergraph Transformer (RHT), a unified architecture that models relational databases as hypergraphs and learns pentadimensional embeddings (PentE). RHT applies sparse relational attention whose complexity scales with the average relational degree, making it computationally efficient for large, high‑dimensional, and high‑cardinality datasets. Experiments on the Synthea synthetic electronic health record dataset show that RHT produces more semantically coherent embeddings than tabular, relational, and temporal graph baselines, while remaining scalable, and the authors provide an open‑source implementation and plan clinical validation on MIMIC‑IV.