arXiv AI

CoMMa: Contribution-Aware Medical Multi-Agents for Decentralized Oncology Decision Support

CoMMa is a decentralized large language model (LLM) agent framework designed for oncology decision support. It allows specialists to work on partitioned clinical data streams, enforcing data decentralization and enhancing role specialization through agent-specific fine‑tuning. The framework introduces a contribution‑aware aggregation mechanism that replaces stochastic reasoning with deterministic embedding projections, enabling explicit credit assignment and a stable, interpretable decision pathway.

arXiv Computation and Language
Sep 1

CARE: Privacy-Compliant Agentic Reasoning with Evidence Discordance

The paper introduces MIMIC-DOS, a dataset derived from MIMIC-IV that focuses on ICU cases where patient symptoms and medical signs are discordant. It presents CARE, a privacy‑compliant multi‑stage agentic reasoning framework that uses a proprietary LLM to generate structured categories and transitions, while a local LLM performs evidence acquisition and decision‑making. In retrospective evaluations on MIMIC‑DOS, CARE outperforms other LLMs and agentic workflows, demonstrating stronger handling of conflicting clinical evidence while preserving patient privacy.

By Haochen Liu, Weien Li, Rui Song, Zeyu Li, Chun Jason Xue, Xiao-Yang Liu, Sam Nallaperuma-Herzberg, Xue Liu, Ye Yuan
arXiv Machine Learning
Sep 22

A Federated Artificial Intelligence Framework for Optimizing Pancreatic Cancer Treatment - Strategy Update

arXiv:2609.24718v1 Announce Type: new Abstract: While a centralized approach involving patient consent to collect and analyze data centrally would theoretically offer the best data quality and predic...

By Anne-Christin Hauschild, Amirreza Aleyasin, Nils H. Beyer, Lisa Fricke, Jonas H\"ugel, Maryam Moradpour, Anh-Tien Nguyen, Youngjun Park, Sophia Rheinl\"ander, Tim Beissbarth, Elisabeth Hessmann, Martin Middeke, Matthias Lauth, Maximilian Reichert, Ulrich Sax
arXiv AI
Aug 25

MACD: Multi-Agent Clinical Diagnosis with Self-Learned Knowledge for LLM

The paper introduces MACD, a Multi-Agent Clinical Diagnosis framework that enables large language models to self‑learn clinical knowledge through a multi‑agent pipeline of summarization, refinement, and application. MACD is extended into a human‑AI collaborative workflow where multiple diagnostician agents consult iteratively, guided by a judge agent and human oversight. Evaluation on the MIMIC‑MACD cohort shows significant gains in diagnostic accuracy—an average 11.6 percentage‑point improvement over authoritative knowledge for open‑weight LLMs and an 18.3‑percentage‑point boost over physician‑only diagnosis in text‑only vignettes.

By Wenliang Li, Rui Yan, Xu Zhang, Li Chen, Hongji Zhu, Jing Zhao, Junjun Li, Mengru Li, Wei Cao, Zihang Jiang, Wei Wei, Kun Zhang, Shaohua Kevin Zhou
arXiv AI
Aug 14

MARC v1: An Open-Source Multi-Agent Framework for Clinical AI Reasoning and Coordination

arXiv:2608. 13476v1 Announce Type: new Abstract: We present Multi-Agent Reasoning and Coordination (MARC), an open-source framework that replaces monolithic LLM prompting with deterministic multi-agent orchestration for clinical reasoning.

By Saisha Shetty, Satvik Tripathi, Austin Lin, Colin Zhao, Theodore Kim, Don Enwerem, Jacinta Arnold, Shahriar Faghani, Tessa S Cook
arXiv AI
Jun 16

MedCollab: IBIS-Guided Multi-Agent Collaboration with Hierarchical Disease Relation Chains for Clinical Diagnosis

arXiv:2603. 01131v3 Announce Type: replace-cross Abstract: Clinical diagnosis is a gradual process of evidence integration, in which physicians move from symptoms and medical history to examinations, competing hypotheses, disease relations, and treatment decisions.

By Yuqi Zhan, Xinyue Wu, Tianyu Lin, Yutong Bao, Xiaoyu Wang, Weihao Cheng, Huangwei Chen, Feiwei Qin, Zhu Zhu