HADRec is a Hierarchy-Aware Drug Recommendation framework that fuses molecular knowledge and electronic health records to improve medication recommendation. It uses LLaMA-7B to encode clinical notes, ChemBERTa to encode drug SMILES strings, and a cross‑attention mechanism for multimodal fusion, while a hierarchical predictor and consistency constraint loss enforce adherence to the ATC classification system. Experiments on MIMIC‑III and MIMIC‑IV show state‑of‑the‑art performance, strong generalization, and well‑calibrated predictions, with counterfactual evaluation indicating clinically aligned reasoning.
By Junke Wang, Hongshun Ling, Li Zhang, Jinjing Wu, Tong Shao, Fang Wang, Yuan Gao
arXiv:2608.20887v1 Announce Type: cross
Abstract: Automatic Medical Coding (AMC), which assigns standardized International Classification of Diseases (ICD) codes to clinical notes, is essential for m...
By Xubin Chen, Yipeng Zhou, Wen Sun, Chengkai Huang, Xiaoming Fu, Quan Z. Sheng
ClinicalGPT‑R1 is a reasoning‑enhanced generalist large language model designed for disease diagnosis. It was trained on 20,000 real‑world clinical records and uses diverse training strategies to improve diagnostic reasoning. In benchmarks, it outperforms GPT‑4o on Chinese diagnostic tasks and matches GPT‑4 performance in English, demonstrating superior disease‑diagnosis capabilities.
By Wuyang Lan, Wenzheng Wang, Changwei Ji, Guoxing Yang, Yongbo Zhang, Xiaohong Liu, Luonan Chen, Shengge Li, Song Wu, Guangyu Wang
arXiv:2505. 02722v2 Announce Type: replace Abstract: Although large language models (LLMs) have demonstrated impressive reasoning capabilities across general domains, their effectiveness in real-world clinical practice remains limited.
By Junu Kim, Chaeeun Shim, Sungjin Park, Su Yeon Lee, Gee Young Suh, Chae-Man Lim, Seong Jin Choi, Song Mi Moon, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Sejoong Kim, Chami Im, Dong-Wan Kang, Yong Soo Kim, Hee-Joon Bae, Sung Yoon Lim, Han-Gil Jeong, Edward Choi
The paper introduces a retrieval‑augmented multi‑agent framework that automatically generates instance‑specific evaluation rubrics for medical language models. By retrieving authoritative medical evidence, decomposing it into atomic facts, and combining these with user interaction constraints, the system produces fine‑grained criteria that outperform GPT‑4o on HealthBench and LLMEval‑Med. The generated rubrics also guide response refinement, improving medical LLM output quality by 9.2%.
By Yinzhu Chen, Abdine Maiga, Hossein A. Rahmani, Emine Yilmaz
arXiv:2609.24480v1 Announce Type: cross
Abstract: Deploying Large Language Models (LLMs) in healthcare requires robust performance across two complementary dimensions - diagnostic reasoning: the conv...
By Kalash Shah, Kunal Singh, Snehan J, Shreyas Singh
arXiv:2606. 02802v1 Announce Type: new Abstract: Large language models (LLMs) exhibit strong natural-language reasoning abilities for clinical decision support, but struggle to effectively model structured longitudinal electronic health records (EHRs).
By Bo-Hong Wang, Baicheng Peng, Ruilin Wang, Jun Bai, Ziyang Song, Yue Li
arXiv:2603.08166v2 Announce Type: replace
Abstract: Automated Drug Combination Extraction (DCE) from large-scale biomedical literature is crucial for advancing precision medicine and pharmacological...
By Zhijun Wang, Ling Luo, Dinghao Pan, Huan Zhuang, Lejing Yu, Yuanyuan Sun, Hongfei Lin
arXiv:2608.22622v1 Announce Type: cross
Abstract: Clinical decision-making relies on identifying relevant patient information to guide diagnosis and treatment, a challenge that is especially difficul...
By Miguel Contreras, Scott Siegel, Subhash Nerella, Jessica Sena, Jiaqing Zhang, Heng Sun, Hruday Tej Akkaladevi, Peiyu Lu, Jordan Rosen, Sumit Kapoor, Sasank Desaraju, Grace R. Thompson, Jacob Purcell, Michael Petrauskis, Philip KW. Hong, Meghan Brennan, Sarah Chrabaszcz, Tierra Smith, Ronnie Ren, Michel S. Kabbash, Ceyhun Haziroglu, Rushi Patel, Gabriel Gomez, Charlotte Chaiklin, Randy Leung, Kenneth N. John, Whitman Wiggins, Philip Kayser, Vincent Bird, Maria Bruzzone, Tyler J. Loftus, Azra Bihorac, Parisa Rashidi
arXiv:2606. 28692v1 Announce Type: new Abstract: Treatment reasoning underpins every therapeutic decision, integrating disease context, comorbidities, medications, contraindications, and evolving biomedical knowledge to select an appropriate therapy.
By Shanghua Gao, Ayush Noori, Richard Zhu, Curtis Ginder, Zhenglun Kong, Xiaorui Su, Justin Kauffman, Benjamin S. Glicksberg, Joshua Lampert, Ankit Sakhuja, Ashwin Sawant, ATHENA-R1 Evaluation Consortium, David A. Clifton, Noa Dagan, Ran Balicer, Marinka Zitnik
Gaokerena is a family of compact Persian medical language models designed for consumer‑grade hardware. The first variant, Gaokerena‑V, was trained on a 90‑million‑token Persian medical corpus and 20,000 physician Q&A pairs, raising a translated medical MMLU benchmark score from 46.28% to 49.31%. A second variant, Gaokerena‑R, adds a Chain‑of‑Thought approach and two Reinforcement Learning with AI Feedback frameworks, achieving a higher benchmark score of 52.98% while also providing uncertainty estimates based on internal hidden states.
By Mehrdad Ghassabi, Hamidreza Baradaran Kashani, Pedram Rostami, Sadra Hakim, Zahra Kazemi, Amirhossein Poursina, Milad Tavakoli, Audrina Ebrahimi
arXiv:2412.15957v2 Announce Type: replace-cross
Abstract: The rapid development of large language models (LLMs) has transformed many industries, including healthcare. In practice, hospitals and patie...
By Ruize Shi, Hong Huang, Wei Zhou, Kehan Yin, Kai Zhao, Yun Zhao