This paper reports a fully localized, low‑resource framework that runs a trillion‑parameter biomedical large language model on a single consumer‑grade RTX 4060 laptop (32 GB system memory, 8 GB VRAM) and routine clinical workstations. The system completes an entire tumor‑paired whole‑genome sequencing workflow—from raw FASTQ input to a clinical‑grade full‑variation‑spectrum report—in 18 hours at 30× depth, achieving a 99.62 % F1 score for somatic variant detection and over 99.9 % concordance with an industrial‑standard A100 cluster pipeline. The study demonstrates that adaptive heterogeneous memory scheduling accounts for 71 % of execution time and that model optimization adds less than 9 % of detection error, establishing a low‑cost, high‑accuracy pathway for global primary medical institutions to adopt precision oncology without expensive GPU clusters.
arXiv:2608.30877v1 Announce Type: new Abstract: Recent advances in large language models (LLMs) have demonstrated exceptional performance in protein-ligand interaction prediction, but state-of-the-ar...
arXiv:2607. 18218v1 Announce Type: cross Abstract: Foundation models have emerged as a driving force in computational pathology, with the potential to transform cancer diagnosis, prognosis, and treatment selection by learning transferable representations from large-scale histopathology data.
arXiv:2604. 26968v2 Announce Type: replace-cross Abstract: Key-value (KV) cache memory management is the primary bottleneck limiting throughput and cost-efficiency in large-scale GPU inference serving.
arXiv:2605. 30716v2 Announce Type: replace-cross Abstract: Generating clinically useful pathology reports for pathology cases from whole-slide images (WSIs) is challenging due to gigapixel resolution, long visual-token sequences, and the complexity of case-level reasoning, where a single case may contain multiple WSIs with heterogeneous tissues and ambiguous findings.
arXiv:2603. 29002v3 Announce Type: replace-cross Abstract: Modern large language models (LLMs) increasingly depends on efficient long-context processing and generation mechanisms, including sparse attention, retrieval-augmented generation (RAG), and compressed contextual memory, to support complex reasoning.
ENAS is a hardware‑aware neural architecture search framework tailored for TinyML on microcontrollers. It uses a static feasibility check, a cell‑based search space with various block types and skip connections, and a three‑stage hybrid search strategy (random → top‑K → mutation) with cross‑run caching. The framework runs efficiently without GPUs, achieving significant search‑time speedups and competitive accuracy on Visual Wake Words and Melanoma Cancer benchmarks across a range of microcontrollers.
arXiv:2609.01202v1 Announce Type: cross Abstract: Clinical trials are essential for advancing cancer care and drug development, but many fail because of insufficient patient enrollment. While there i...
arXiv:2506. 20686v2 Announce Type: replace-cross Abstract: Recent advances in biomolecular modeling have been catalyzed by models such as AlphaFold3 (AF3), which introduce science-informed changes to the transformer architecture.
arXiv:2506. 01969v3 Announce Type: replace-cross Abstract: Efficient inference of Multi-Head Latent Attention (MLA) is challenged by deploying the DeepSeek-R1 671B model on a single Multi-GPU server.
arXiv:2608.28708v1 Announce Type: cross Abstract: Prospective silent trials provide an important bridge between retrospective validation of artificial intelligence (AI) models and their use in clinic...
arXiv:2608. 10506v1 Announce Type: cross Abstract: Accurate pre-deployment estimation of CNN inference cost--energy, latency, and peak memory--is increasingly critical as models are deployed on resource-constrained GPU platforms.
arXiv:2509.21275v5 Announce Type: replace-cross Abstract: Long context training is crucial for extending LLM context windows. Existing schemes, such as sequence parallelism, incur substantial communi...