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This paper reports a fully localized, low‑resource framework that runs a trillion‑parameter biomedical large language model on a single consumer‑grade RTX 4060 laptop (32 GB system memory, 8 GB VRAM) and routine clinical workstations. The system completes an entire tumor‑paired whole‑genome sequencing workflow—from raw FASTQ input to a clinical‑grade full‑variation‑spectrum report—in 18 hours at 30× depth, achieving a 99.62 % F1 score for somatic variant detection and over 99.9 % concordance with an industrial‑standard A100 cluster pipeline. The study demonstrates that adaptive heterogeneous memory scheduling accounts for 71 % of execution time and that model optimization adds less than 9 % of detection error, establishing a low‑cost, high‑accuracy pathway for global primary medical institutions to adopt precision oncology without expensive GPU clusters.
arXiv:2608. 10506v1 Announce Type: cross Abstract: Accurate pre-deployment estimation of CNN inference cost--energy, latency, and peak memory--is increasingly critical as models are deployed on resource-constrained GPU platforms.
arXiv:2602. 22822v3 Announce Type: replace Abstract: Tandem mass spectrometry (MS/MS) is central to small molecule identification, but current deep learning systems for spectrum prediction still remain difficult to evaluate and deploy in practice.
TopU-LBVS is a new multi‑target benchmark for ligand‑based virtual screening that addresses shortcomings of existing datasets by using hard‑negative decoys and a fixed 1:40 active‑to‑decoy ratio. It covers 93 protein targets across seven classes, provides three evaluation protocols (full, low‑data, and mini), and includes curated ChEMBL‑35 bioactivity data with property‑matched, structurally similar decoys. The benchmark demonstrates that performance drops sharply when moving from random‑decoy to hard‑negative evaluation, and it releases data, splits, code, and baseline implementations for reproducible comparison.
ENAS is a hardware‑aware neural architecture search framework tailored for TinyML on microcontrollers. It uses a static feasibility check, a cell‑based search space with various block types and skip connections, and a three‑stage hybrid search strategy (random → top‑K → mutation) with cross‑run caching. The framework runs efficiently without GPUs, achieving significant search‑time speedups and competitive accuracy on Visual Wake Words and Melanoma Cancer benchmarks across a range of microcontrollers.
Accurate pre-deployment estimation of CNN inference cost--energy, latency, and peak memory--is increasingly critical as models are deployed on resource-constrained GPU platforms. Existing approaches rely on FLOPs, latency measurements, or single-device profiling as energy proxies, overlooking the non-linear interactions between architectural design and hardware load.