arXiv:2606. 31616v1 Announce Type: new Abstract: Medical Artificial Intelligence (AI) is widely expected to transform clinical practice, yet the decision-making processes of many Machine Learning (ML) models remain opaque.
By Martina Mattioli, Marcello Pelillo
arXiv:2606. 16149v3 Announce Type: replace Abstract: Rare disease diagnosis depends on expert reasoning that is scarce and difficult to transfer; off-the-shelf large language models (LLMs) rank the correct disease first in only 35.
By Minh-Ha Nguyen, Erica Gray, Bryce A. Schuler, Kevin W. Byram, Chih-Ting Yang, Fan Ma, Hua Xu, Wu-Chen Su, Chao Yan, Wei-Qi Wei, Adam Wright, Lisa Bastarache, Josh Peterson, Lingyao Li, Siyuan Ma, Undiagnosed Diseases Network, Rizwan Hamid, Thomas A. Cassini, Cathy Shyr
arXiv:2606.16149v5 Announce Type: replace
Abstract: Rare disease diagnosis depends on expert reasoning that is scarce and difficult to transfer. Large language models rank the correct disease first i...
By Minh-Ha Nguyen, Erica Gray, Bryce A. Schuler, Kevin W. Byram, Chih-Ting Yang, Fan Ma, Hua Xu, Wu-Chen Su, Chao Yan, Wei-Qi Wei, Adam Wright, Lisa Bastarache, Josh F. Peterson, Lingyao Li, Siyuan Ma, Undiagnosed Diseases Network, Rizwan Hamid, Thomas A. Cassini, Cathy Shyr
arXiv:2608.30393v1 Announce Type: new
Abstract: Biomedical artificial intelligence (AI) systems increasingly extract, organize, and reuse scientific claims from literature, clinical trials, and regul...
By Negin Sadat Babaiha, Stefan Geissler, Marie-Christine Simon, Martin Hofmann-Apitius, Marc Jacobs
arXiv:2609.34780v2 Announce Type: replace
Abstract: The use and applicability of artificial intelligence (AI) in medical research and clinical practice has received increasing attention in the litera...
By Erik Aerts
The article argues that large language models (LLMs) are inadequate for consequential quantitative tasks such as pricing, risk assessment, and medical triage because language is a lossy representation of quantitative data that cannot be reversed. It formalizes this limitation as a property of the training representation rather than model capacity and identifies three essential properties—reproducibility, traceable lineage to source records, and calibrated uncertainty—that language substrates cannot provide. The authors propose a new class of models, Large Quantitative Models (LQMs), designed to meet these requirements.
By Reuben Vandeventer, David Imrem, David J. Wild