arXiv Computer Vision By Guangyu Meng, Pengfei Gu, Peixian Liang, John P. Lalor, Erin Wolf Chambers, Danny Z. Chen

VTRL-Med: Progressive Visual Refinement with Topology-Guided Regularization for Medical Image Clustering

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VTRL-Med is a progressive visual‑structural learning framework that incorporates topology‑guided regularization for medical image clustering. It adapts the Segment Anything Model to preserve structural cues, generates pseudo‑labels via prototype selection and k‑NN consistency, and refines visual features while an auxiliary topology branch—built from persistent homology descriptors—provides geometric regularization. The method achieves state‑of‑the‑art clustering accuracy, improving average performance by 4.48% over prior approaches and further boosting accuracy by 1.3–4.3% with topology guidance.

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