arXiv Machine Learning By Dattatreya Kantha, Murray H. Loew

Pretreatment MRI reveals a latent, molecular-subtype-independent structural phenotype that organizes treatment trajectories and recurrence risk

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arXiv:2607. 02768v1 Announce Type: cross Abstract: Pathologic complete response and tumor shrinkage measure whether breast cancer responds to neoadjuvant therapy, but not whether that response was structurally favorable, persistent, or hidden beneath volume loss.

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arXiv Machine Learning
Jul 16

Multimodal Empirical Bayes Variational Autoencoders for Joint Longitudinal and Time-to-Event Modeling

arXiv:2607. 13984v1 Announce Type: cross Abstract: Longitudinal tumor measurements, dropout information, and genetic covariates provide complementary information about treatment response, but integrating these data sources within a single population modeling framework remains challenging.

By Anders Sj\"oberg, Nils Olsson, Marcus Baaz, Mats Jirstrand
arXiv AI
Aug 5

Spatial proteomics guided by H&E-based AI reveals recurrence-risk niches in triple-negative breast cancer

arXiv:2608. 03145v1 Announce Type: new Abstract: Deep learning models can predict cancer recurrence from H&E stained slides, but the localized molecular states underlying these predictions remain largely obscured.

By Yesung Cho, Ji Hwan Park, Chanil Kim, Hyewon Kim, Honglan Li, Yumin Lee, Geongyu Lee, Sujeong Hong, Seong Min Park, Yoonyoung Lee, Hee Sool Rho, Sumin Lee, Amos Chungwon Lee, Changhwan Lee, Hwanyoung Shim, Hyunwook Kim, Hyeji Shin, Sanha Park, Jihoon Yu, Yoon Hee Shin, Sooheon Kim, Hyunjin Park, Seung Min Park, Sangwan Kim, Yujung Kim, Sung-Im Do, Eun-Young Kim, Dongmyung Shin, Jongbae Park, In-Gu Do
arXiv Machine Learning
Aug 26

A Multimodal Foundation Model for Longitudinal Patient Representation and Scalable Insight Generation in Oncology

arXiv:2608.24688v1 Announce Type: new Abstract: Precision oncology necessitates a longitudinal model of patient state that captures cancer evolution and treatment over time, integrating multimodal ob...

By Eugene Vorontsov, Yi Kan Wang, Alican Bozkurt, Adam Casson, Ludmila Tydlitatova, Michal Zelechowski, Ezra E. W. Cohen, Jyoti D. Patel, Max Banaszak, Caitlin McWilliams, Shane Colley, Kate Sasser, Ryan Fukushima, Eric Lefkofsky, Razik Yousfi, Siqi Liu
arXiv Computer Vision
Sep 23

Neoadjuvant chemotherapy response prediction using pretreatment diffusion and contrast-enhanced magnetic resonance imaging with clinical variables

arXiv:2609.26105v1 Announce Type: cross Abstract: Prediction of pathological complete response before neoadjuvant chemotherapy may facilitate more tailored therapeutic planning for breast cancer pati...

By Pablo Garc\'ia Marcos, Paula Puerta Gonz\'alez, Guillermo Lorenzo, H\'ector G\'omez, Covadonga del Camino, Ad\'an Rodr\'iguez, Ignacio Pel\'aez, Angel Rio-Alvarez, V\'ictor M. Gonz\'alez
arXiv Machine Learning
Sep 23

Foundation model embeddings capture pre-diagnostic changes on screening mammograms

The study examined whether embeddings from four foundation models—Mammo-CLIP, HOPPR, MedImageInsight, and BiomedCLIP—could detect pre‑diagnostic changes in screening mammograms. Using 1,773 biopsied women and matched controls, the researchers measured the speed of movement along a data‑derived “cancer direction” in embedding space over successive screening intervals. They found that embeddings from clinically grounded models (Mammo‑CLIP, HOPPR, MedImageInsight) showed faster drift in malignant cases compared to controls, while the general biomedical model BiomedCLIP did not, indicating that foundation model embeddings can encode early tissue changes without task‑specific fine‑tuning.

By Kalina P. Slavkova, Eric Brattain, Aditya Gowd, Akash Pattnaik, Jean-Benoit Delbrouck, Matthew Morgan, Julie Bauml, Javid Abderezaei, Khan Siddiqui