The paper introduces SV-Cine, a cardiac MRI segmentation framework tailored for single ventricle physiology (SVP). It combines a generative data augmentation pipeline that creates synthetic 3D cardiac meshes and MRI, with a diagnosis-conditioned adaptation of the CineMA foundation model that uses patient-level diagnostic information to improve segmentation. Evaluations on an internal cohort show high Dice scores for left and right ventricles, outperforming nnU-Net, and demonstrate that incorporating diagnosis priors can adapt a pretrained model to specialized SVP tasks.
By Lila Cunge, Yuehong Liu, Hang Xu, Thomas Coudert, Pierangelo Renella, J Paul Finn, William Hsu, Kim-Lien Nguyen
The paper presents a two‑stage framework for prenatal congenital heart disease (CHD) screening that operates directly on whole fetal ultrasound studies. It first learns transferable frame representations via self‑supervised masked‑autoencoder pre‑training, then identifies cardiac frames with a disease‑robust module and aggregates them using a transformer‑based multiple instance learning model to produce a case‑level diagnosis. The approach achieves high performance (AUC 0.985, specificity 0.990) on an internal test set and, after label‑free CORAL adaptation, improves to an AUC of 0.944 on an external cohort, outperforming existing baselines.
By Mohamed Azzam, Ruobing Liu, Esther C. Ugwueke, Ziyang Xu, Shibiao Wan, Alex Foy, Abraham Zabih, Jason Christensen, Neil Hamill, Ling Li, Jieqiong Wang
The paper presents the first systematic evaluation of out‑of‑distribution generalization for congenital heart disease (CHD) segmentation, using the ImageCHD cohort as a held‑out target. It compares several segmentation architectures under different training regimes, showing that in‑distribution performance is a poor predictor of cross‑cohort robustness: nnU‑Net drops from 0.77 to 0.51 Dice, while SwinUNETR maintains higher performance at 0.67 Dice. Limited target‑domain adaptation with only 11 labeled ImageCHD cases boosts all SwinUNETR variants above 0.76 Dice, highlighting the importance of explicit cross‑dataset testing.
By Aniketh Vijesh, Shrisharanyan Vasu, Abhijit Ramesh, Clare Pomeroy-Ward, Harikrishnan Anil Maya, Sarin Xavier, Mahesh Kappanayil, Gilad Gressel
Congenital heart disease (CHD) diagnosis and surgical planning often require patient-specific 3D anatomical models, but manual segmentation is labor-intensive, particularly in complex anatomies. Altho...
arXiv:2510. 12953v4 Announce Type: replace-cross Abstract: Recent medical vision-language models have shown promise on tasks such as VQA, report generation, and anomaly detection.
By Xiao He, Huangxuan Zhao, Guojia Wan, Jiancheng Pan, Yanxing Liu, Yong Luo, Juhua Liu, Yongchao Xu, Wei Zhou, Dacheng Tao, Bo Du
arXiv:2606. 00123v1 Announce Type: cross Abstract: Multimodal Large Language Models (MLLMs) have shown strong performance on public medical benchmarks, yet existing evaluations often remain weak proxies for clinical use, relying on isolated inputs and simplified recognition-style tasks.
By Zixian Su, Hongkai Zhang, Fan Gao, Encheng Su, Taiping Qu, Jingwei Guo, Nan Zhang, Hui Wang, Zhen Zhou, Kairui Bo, Yan Chen, Yue Ren, Shuai Li, Lei Xu, Henggui Zhang