Physics-Informed Conditional Diffusion for Motion-Robust Retinal Temporal Laser Speckle Contrast Imaging

The paper introduces RetinaDiff, a physics‑informed conditional diffusion framework for retinal temporal laser speckle contrast imaging (tLSCI). It first stabilizes speckle sequences via phase‑correlation registration, then uses a motion‑corrected contrast prior to guide a diffusion model that reconstructs high‑quality tLSCI maps from only a few frames. Experiments on an in‑house retinal LSCI system show significant improvements in SSIM, PSNR, and FID compared to conventional five‑frame reconstruction, even in challenging cases.

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• diffusion