The paper presents a framework that merges single‑cell perturbation experiments with population‑scale single‑cell data to perform causal path analysis of gene regulation. It incorporates externally learned ancestral relationships to constrain network topology, re‑estimates direct edges from population data, and applies a surrogate‑variable procedure plus errors‑in‑variables correction to handle multiscale heterogeneity and measurement error. The authors provide theoretical guarantees for confounder recovery and high‑dimensional estimation, and demonstrate the method’s effectiveness through simulations and an acute myeloid leukemia case study that uncovers distinct regulatory pathways linking transcriptional regulators to blast count.
By Kwangmoon Park, Hongzhe Li
arXiv:2607. 04527v1 Announce Type: cross Abstract: Biological systems exhibit a hierarchical structure, characterised by directed flow from upstream regulators to downstream effects.
By Stephen Asiedu, David Watson
PopPert is a framework that models population-level joint gene expression distributions to predict transcriptional responses to perturbations in single-cell RNA sequencing data. By using a low‑rank Gaussian Copula, it captures gene co‑expression patterns and eliminates the need for cell‑to‑cell correspondence, thereby reducing sensitivity to single‑cell noise. Across multiple benchmarks, PopPert outperforms existing methods in differential expression recovery, perturbation effect estimation, and distribution matching, demonstrating the effectiveness of population‑level joint distribution learning for unpaired single‑cell data.
By Handong Wang, Jiaxin Qi, Haochen Feng, Baisheng Lai
arXiv:2606. 24488v1 Announce Type: cross Abstract: Learning causal models from fragmented biomedical data is challenging because clinical, molecular, and imaging variables are often incomplete or not jointly observed.
By Inam Ullah, Imran Razzak, Shoaib Jameel
arXiv:2606. 07914v1 Announce Type: cross Abstract: We study component recovery and mixing-matrix estimation from unlabeled finite mixtures whose observable distributions share the same latent components but have unknown mixing weights.
By Takafumi Kanamori, Yushi Hirose, Shohei Yamamoto
arXiv:2606. 00685v1 Announce Type: new Abstract: Gene regulatory networks (GRNs) capture transcription factor-target interactions and are central to understanding cell-state regulation and disease.
By Tianyang Xu, Tianci Liu, Niraj Rayamajhi, Ryan Patrick, Kranthi Varala, Ying Li, Jing Gao