OA-MAP: Evidence-Grounded Multi-Agent Multimodal Framework for Interpretable Knee Osteoarthritis Progression

OA-MAP is an autonomous multi‑agent multimodal framework designed to predict knee osteoarthritis progression by integrating MRI, X‑ray, and clinical data. The system employs modality‑specific agents and a coordinator to autonomously select predictive tools, retrieve supporting literature, and provide interpretable risk estimates. In a study of 600 participants, the fusion models achieved AUROCs of 0.80 for structural progression and 0.68 for pain progression, and a case study demonstrated how OA‑MAP combines risk estimates, intermediate findings, literature support, and uncertainty indicators for interactive clinician review.

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• agents
• multimodal