MS-Exam-Gen: An Automatic Benchmark Construction Toolkit for Evaluating LLMs on Multiple Sclerosis-MRI Imaging Knowledge
Read the original on arXiv AI →The Flow has not summarised this story yet — read it at arXiv AI.
The Flow has not summarised this story yet — read it at arXiv AI.
MS-Exam-Gen is a reproducible framework that builds a source‑grounded multiple‑choice question benchmark for evaluating large language models on knowledge about multiple sclerosis MRI. The pipeline uses expert‑indexed sources, topic induction, evidence‑grounded MCQ generation, automated quality audits, and consistency checks to produce a 3,058‑item benchmark covering 16 topics and 53 subtopics. Evaluation of 12 LLM endpoints on this benchmark revealed a wide accuracy range (89.7% to 46.9%) and identified items frequently missed by models, while audits showed reduced answer cues and position‑sensitivity in scoring.
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The study evaluates Jev 1.13, a non‑generative model that selects from predefined answer options, on four medical benchmarks: MetaMedQA, PubMedQA, DiagnosisArena‑MCQ, and the NEJM Case Challenges. Jev’s top‑1 accuracy matches GPT‑6 Sol with medium reasoning on PubMedQA but falls behind on MetaMedQA, DiagnosisArena‑MCQ, and NEJM cases. While Jev shows strong calibration on MetaMedQA and is fast and inexpensive, its performance on examination and complex diagnostic tasks is substantially lower, indicating the need for task‑specific validation before clinical deployment.
An integrated, web‑based platform has been developed to process diffusion‑weighted imaging (DWI) from MR‑guided linear accelerators and provide structured, literature‑grounded clinical interpretations. The system combines a deep‑learning pipeline for distortion correction, denoising, and IVIM/ADC fitting with a retrieval‑augmented generation (RAG) agent that references a curated knowledge base and traces each statement to its source. Independent expert ratings of nine glioblastoma cases showed high scores for clinical reasoning, citation quality, and overall utility, with a mean rating of 4.65 out of 5.
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