M4Bench is a benchmark comprising 28 clinical derivation tasks across 15 families on MIMIC‑IV and eICU, designed to evaluate whether AI coding agents can reproduce complex procedural specifications for electronic health record (EHR) variable derivation. The study tests agents with and without clinician‑reviewed skill sets, finding that specification completeness drives most performance gains, while generic context or skill format contribute little. The benchmark includes tasks, skills, evaluation code, and sanitized evidence, all released as open‑source.
By Hannes Ill, Rafi Al Attrach, Rajna Fani, Ahram Han, Ryohei Yamamoto, Marlene Louisa Moerig, Dukyong Yoon, Leo Anthony Celi
arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.
By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv:2607. 10113v1 Announce Type: new Abstract: Large language model agents increasingly store reusable procedures outside the model.
By Yubo Li
arXiv:2606. 14239v1 Announce Type: new Abstract: Agent skills are structured procedural packages that guide frozen LLM agents in specialized workflows.
By Haowen Gao, Haoran Chen, Can Wang, Shasha Guo, Liang Pang, Zhaoyang Liu, Huawei Shen, Xueqi Cheng
SkillNEO introduces a non‑elitist evolutionary framework for refining agent skills, allowing lower‑reward versions to receive further edits and preserve useful partial repairs. By separating the selection of a version to use from the selection of versions to improve, the method identifies which steps to keep and which failures to fix, even revisiting earlier versions with new evidence. Experiments on 86 SkillsBench tasks across eight domains show significant reward gains for GPT‑5.4 Mini and substantial improvements when the evolved skills are reused by stronger models such as GPT‑5.5 and GPT‑5.6 Luna.
By Enze Ma, Chunyu Miao, Yankai Chen, Jie Yang, Liancheng Fang, Kening Zheng, Hanrong Zhang, Muyao Xu, Xinle Yu, Chengze Li, Wei-Chieh Huang, Ziwei Ren, Yunhao Du, Zhixiang Shen, Xue Liu, Philip S. Yu, Zhen Wang
arXiv:2608. 07796v1 Announce Type: new Abstract: Large language models perform strongly on medical knowledge benchmarks, but reliable clinical deployment requires agents to conduct defensible investigations over heterogeneous, longitudinal records: determining what evidence is needed, retrieving and reconciling structured and free-text data, grounding conclusions in verifiable evidence, and deferring cases that cannot be resolved reliably.
By Veronica Chatrath, Bryan Zhu, George Pu, Jingxuan Fan, Apaar Shanker, Varun Ursekar, Anahita Sharma, Jason Qin, Keqi Han, Soham Dinesh Tiwari, Soham Dan, Vijay Kalmath, Yuan Li, Daniel Yue Zhang, Chenguang Wang, Zainab Doctor, Zhijun Yin, Nigam H. Shah, Yuan Xue