← Back to all news
arXiv AI By Sina Raeisadigh, Henning M\"uller, Abderrahmane Hedjoudje

Interpretable Multimodal MRI-Clinical Fusion for Functional Outcome Prediction After Acute Ischemic Stroke

Read the original on arXiv AI →

This study assessed whether day‑1 multimodal MRI can improve prediction of three‑month functional outcome after acute ischemic stroke. Using pretrained ResNet embeddings from ADC, DWI, and FLAIR scans combined with clinical data, the authors found that clinical‑only models performed well (AUC≈0.90), while MRI‑only models were less discriminative (AUC≈0.67‑0.73). Among multimodal combinations, FLAIR‑clinical fusion yielded the best performance (AUC≈0.95), with age, NIHSS subscores, ADC lesion burden, and learned FLAIR features identified as key contributors.

Machine-generated by The Flow from the publisher's headline and feed description — not written or checked by a human. The full article lives at arXiv AI.

Related stories

arXiv AI
Sep 1

Federated Learning for MRI-based BrainAGE: a multicenter study on post-stroke functional outcome prediction

arXiv:2506.15626v3 Announce Type: replace-cross Abstract: $\textbf{Objective:}$ Brain-predicted age difference (BrainAGE) is a neuroimaging biomarker reflecting brain health. However, training robust...

By Vincent Roca, Marc Tommasi, Paul Andrey, Aur\'elien Bellet, Markus D. Schirmer, Hilde Henon, Laurent Puy, Julien Ramon, Gr\'egory Kuchcinski, Martin Bretzner, Renaud Lopes
safety
More like this →
arXiv Computer Vision
Sep 14

Learning Sparse Latent Predictive Foundation Model for Multimodal Neuroimaging

The paper introduces Neuro‑JEPA, a sparse multimodal foundation model that learns unified representations of brain MRI across T1w, T2w, and FLAIR sequences using a latent predictive objective and a Mixture‑of‑Experts architecture. It was pretrained on over 1.5 million scans from 428,647 studies and systematically evaluates architectural, masking, objective, and sparsity choices for robust multimodal representation learning. Across 47 tasks from three health systems and 12 public datasets, Neuro‑JEPA consistently outperforms a simple CNN baseline, demonstrating its effectiveness for both clinical and research applications.

By Haoxu Huang, Long Chen, Jingyun Chen, Jinu Hyun, James Ryan Loftus, Kara Melmed, Daniel Orringer, Jennifer Frontera, Seena Dehkharghani, Arjun Masurkar, Narges Razavian
efficiencymultimodalbenchmarks
More like this →
arXiv Computer Vision
Sep 14

A Multimodal Explainable Deep Learning Framework for Alzheimer's Disease Diagnosis using 3D Magnetic Resonance Imaging and Clinical Data

The study presents an explainable multimodal deep‑learning framework that combines a 3D CNN for T1‑weighted MRI with a feedforward network for harmonized clinical and demographic data to diagnose Alzheimer’s disease. Using 6,479 ADNI records and 1,703 OASIS‑3 records, the authors compare various model configurations on three‑way and pairwise diagnostic tasks, finding that performance and explanations vary by task, modality, fusion strategy, and cohort. SHAP and Integrated Gradients consistently highlight the MMSE score as the most influential tabular feature, while CAM‑based explanations differ across model setups and cohorts, indicating that explainability is not a stable property under cohort shift.

By Yusuf Brima, Marcellin Atemkeng, Lakshmana Rao Namamula, Antoine Vacavant
multimodal
More like this →
arXiv AI
Jun 9

Comparative evaluation of training strategies using partially labelled datasets for segmentation of white matter hyperintensities and stroke lesions in FLAIR MRI

arXiv:2601. 20503v2 Announce Type: replace-cross Abstract: White matter hyperintensities (WMH) and ischaemic stroke lesions (ISL) are key imaging biomarkers of cerebral small vessel disease (SVD) detectable on magnetic resonance imaging (MRI).

By Jesse Phitidis, Alison Q. Smithard, William N. Whiteley, Joanna M. Wardlaw, Miguel O. Bernabeu, Maria Vald\'es Hern\'andez
computer-visionefficiency
More like this →
arXiv AI
Jun 17

Probing, Fusion, and Trustworthiness: A Systematic Evaluation of Foundation Model Representations for Multimodal Cancer Analysis

arXiv:2606. 17115v1 Announce Type: cross Abstract: Foundation models (FMs) have emerged as powerful representation extractors for medical data, yet their generalizability to datasets under distribution shift remains underexplored.

By Jingyu Hu, Giuseppe Tripodi, Reed Naidoo, Sarah F. McGough, Tapabrata Chakraborti
multimodalbenchmarks
More like this →