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The article reviews how cardiac imaging techniques such as echocardiography, CMR, and CT can be integrated with bulk, single-cell, and spatial transcriptomics to create joint representations that link imaging phenotypes to detailed molecular states. It outlines the representation needs of each modality, compares multimodal fusion strategies, and synthesizes pipelines for radiogenomics, spatial alignment, and image-based gene‑expression prediction, while discussing validation, limitations, and failure modes. The review highlights emerging spatial multiomic maps of human myocardium and atherosclerotic plaque, noting that cost, scalability, and tissue availability remain major barriers to large‑scale cardiovascular translation.
The paper introduces BCARP, a Biology‑Guided Context‑Aware Residual Propagation framework that predicts spatial gene expression from H&E‑stained histology images. Rather than directly decoding expression from visual features, BCARP treats histology embeddings as morphological priors and iteratively refines spot representations in a transcriptomics‑oriented latent space, integrating nuclei‑guided local context and prototype‑guided global propagation. Evaluations on three spatial transcriptomics datasets and ten HEST‑1k cohorts show that BCARP outperforms existing baselines in mean correlation‑based metrics, demonstrating the effectiveness of biology‑guided local‑global residual propagation for histology‑to‑transcriptomics prediction.
The paper presents a Multi‑Scale Graph Neural Network that predicts bulk, spatial, and single‑cell gene expression directly from whole‑slide histopathology images. It uses a Pathology Foundation Model to extract morphological features and builds spatial graphs at patch and cell levels, training on TCGA, Visium, and Xenium data from lung, kidney, and breast tissues. The model achieves accurate slide‑level predictions, moderate patch‑level accuracy (especially on Xenium), and moderate single‑cell correlation, and its outputs are shown to be useful for survival analysis, spatial hazard mapping, and tumor classification.
arXiv:2607. 14410v1 Announce Type: new Abstract: Spatially resolved omics studies increasingly combine transcriptomic and epigenomic assays, yet downstream analysis is often still performed using single-modality pipelines.
arXiv:2606. 03644v1 Announce Type: new Abstract: Comprehensive molecular profiling is essential for modern precision oncology but remains hindered by prohibitive costs, specimen exhaustion, and protracted turnaround times.
arXiv:2606. 28179v1 Announce Type: cross Abstract: Identifying robust associations between cardiac imaging phenotypes and clinical diseases is fundamental to population-scale cardiovascular research and reliable risk stratification.