ClinAgent is a conversational system that uses a ReAct-based LLM agent to retrieve and synthesize clinical trial information from multiple sources such as ClinicalTrials.gov, PubMed, and a local dataset. The agent iteratively reasons over user queries, selects appropriate tools, and refines its actions to provide grounded, up-to-date responses in natural language across multi-turn interactions. Evaluation across three phases shows that DeepSeek (thinking mode) excels in planning quality while Gemini 3.0 Flash delivers the highest overall performance and expert ratings, demonstrating the promise of agentic AI for improving clinical trial data access.
By Antonino Vaccarella, Riccardo Cantini, Domenico Talia, Paolo Trunfio, Marianna Talia, Rosamaria Lappano, Marcello Maggiolini
ReviewPilot is a conversational multi‑agent system designed to automate the PRISMA workflow for systematic literature reviews, covering both paper screening and evidence extraction. Researchers can customize screening criteria and extraction schemas through dialogue, with a project memory preserving configurations and revisions. The system records the rationale for each screening decision and the source of every extracted value, and it has demonstrated superior performance to single‑prompt LLMs and AgentSLR in epidemiology, achieving screening macro F1 scores up to 0.776 and extraction F1 up to 0.788, while also showing close agreement with human annotators in biomedicine and human‑computer interaction case studies.
By Zhaoqian Xue, Shaoze Zhou, Xuexin Li, Junting Mu, Haozheng Liu, Zhongyin Wang, Yichun He, Renkai Ma, Hao Zhou, Sarah Bratt, Siyuan Ma, Chen Chen, Lingyao Li
arXiv:2609.36392v1 Announce Type: new
Abstract: In diseases where clinical guidelines are incomplete, contested, or mutually contradictory, knowledge completeness and dynamic conflict-aware synthesis...
By Yuyan Chen
arXiv:2610.16108v1 Announce Type: new
Abstract: Maintaining up-to-date clinical practice guidelines (CPGs) is essential for evidence-based medicine, but rapid evidence growth and complex expert conse...
By Yuanfan Lin, Jie Di, Xujin He, Zhenzhe Lin, Jialing Chen, Ruiyang Li, Changyu Zheng, Yuanrui Shang, Weiqin Peng, Jingxi Qin, Xiong Wang, Dongxin Ye, Yining Huang, Guoqiang Li, Andi Xu, Sijia Yu, Ruixin Wang, Yahan Yang, Xiaohang Wu, Duoru Lin, Jingjing Chen, Zhenzhen Liu, Wenben Chen, Haotian Lin
The paper introduces BRIE, a continuously maintainable benchmark for evaluating large language models (LLMs) in electronic health record (EHR) information retrieval. It presents a scalable framework that automatically generates question–answer pairs from longitudinal EHR notes, validated by nineteen clinicians. The benchmark allows assessment of multiple inference strategies and highlights that state‑of‑the‑art LLMs often miss clinically important information, especially when synthesis across documents is required.
By Jordan L. Cahoon, Chloe O. Stanwyck, Sulaiman Somani, Philip Chung, Kevin R Keet, Kameron C. Black, Andrea T. Fisher, Sarita Khemani, Jerry Liu, Stephen Ma, Saloni K. Maharaj, Rita M. Pandya, Eduardo Perez-Guerrero, Priyanka Pillai, Lisa Shieh, David J. H. Wu, James Xie, James C. McAvoy, Teresa Nguyen, Jessica Tran, Lucy Yin, Bridget Lin, Alison Callahan, Jason A. Fries, Nigam H. Shah, Emily Alsentzer
arXiv:2609.38480v1 Announce Type: cross
Abstract: Most clinical benchmarks evaluate language models (LMs) on diagnosis using complete case descriptions. In clinical practice, however, patients presen...
By Xueting Fang, Zehui Li, Yang Yang, Camilla Giovino, Shubh K. Patel, Shailly Prajapati, Vallijah Subasri, Caihua Shan