Geometry-anchored PET-aware multimodal pseudo-CT synthesis for whole-body attenuation correction: the BIC-MAC Challenge
Read the original on arXiv Computer Vision →The Flow has not summarised this story yet — read it at arXiv Computer Vision.
The Flow has not summarised this story yet — read it at arXiv Computer Vision.
The paper presents a multimodal 3D patch-based U‑Net for generating pseudo‑CT images from non‑attenuation‑corrected PET (NAC‑PET), MRI, and 2D topograms. It employs separate PET and MR encoders, multi‑scale feature fusion, and FiLM‑based topogram conditioning at the bottleneck to integrate complementary cross‑modal information while reducing dependence on precise voxel‑wise correspondence. The authors participated in the BIC‑MAC Challenge and released their final model on GitHub.
The paper presents a method for the BIC-MAC challenge, aiming to generate pseudo‑CT images from NAC‑PET, DIXON MRI, and a topogram, and to evaluate both the pseudo‑CT and the resulting attenuation‑corrected PET. The authors improve upon a 3D U‑Net baseline by focusing on loss design: they compute an L1 error in the Carney attenuation‑coefficient space, weighted by anatomical region, and incorporate DIXON MRI as additional input only after this loss was applied. Finally, they fuse two independently trained models via a fixed convex combination, achieving better performance than either model alone and topping the public validation leaderboard.
The paper introduces a one‑pass conditional 3D rectified flow (3D Flow) framework for denoising whole‑body PET images, employing an optimized non‑uniform sampling strategy and a linear‑interpolant velocity‑matching objective. It reconstructs a full 3D volume in about 30 seconds, dramatically faster than multi‑hour 3D diffusion models, while maintaining high global image quality and lesion conspicuity even at ultra‑low doses (down to 1/100 of standard). Zero‑shot transfer tests on independent clinical data demonstrate robust performance across datasets and unseen dose levels.
arXiv:2606. 13341v1 Announce Type: cross Abstract: We present a Dual-Domain Equivariant Generative Adversarial Network (DDE-GAN) for multimodal CT-PET image synthesis.
arXiv:2608. 19666v1 Announce Type: new Abstract: Deep learning-based whole-body PET-CT lesion segmentation can support cancer staging, treatment planning, and response assessment, but generalization is limited by scarce annotations and domain shifts.
Generating CT volumes from MRI and CBCT can improve treatment planning in adaptive radiotherapy while avoiding additional radiation exposure. However, direct regression of CT intensities is challenged by the inherently high dynamic range and long-tailed distributions, thereby averaging out sparse yet clinically important structures.