Genetic algorithm vs. gradient descent for training a neural network architecture dedicated to low data regimes in small medical datasets

The paper compares genetic algorithm (GA) and gradient descent (GD) training for a distance‑encoding biomorphic‑informational neural network (DEBI‑NN) designed for low‑data medical datasets. A spatial backpropagation scheme was implemented for GD, and both optimizers were evaluated on synthetic, radiomic, and fetal cardiotocography datasets. Across all experiments, GA consistently outperformed GD, achieving higher classification accuracy and more stable decision boundaries, while GD struggled with the interdependent spatial parameters of DEBI‑NN.

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