Comparative Study of Anatomical and Learned Features in AI Models for Structural Brain MRI
Read the original on arXiv AI →The Flow has not summarised this story yet — read it at arXiv AI.
The Flow has not summarised this story yet — read it at arXiv AI.
arXiv:2610.28411v1 Announce Type: cross Abstract: Deep learning models have become essential tools in medical imaging, yet training them end-to-end for diverse tasks remains challenging due to limite...
arXiv:2607. 17782v1 Announce Type: cross Abstract: Foundation models pretrained using self-supervised learning have transformed computer vision by learning transferable representations from large-scale unlabeled data.
arXiv:2610.00279v1 Announce Type: new Abstract: The segmentation of anatomical structures in medical images and particularly in MRI scans, is essential for clinical diagnosis and monitoring disease p...
The paper investigates combining a domain‑specific self‑supervised task—voxel‑level brain age prediction—with a general task—image inpainting—to pretrain models for brain MRI segmentation. A multitask pretraining framework jointly optimizes both objectives, yielding representations that outperform single‑task pretraining and training from scratch on three segmentation benchmarks (multiple sclerosis lesions, ischemic stroke lesions, and cortical structures). The study demonstrates that integrating domain‑specific and general self‑supervised tasks benefits the development of generalizable neuroimaging foundation models.
The paper presents a multimodal 3D convolutional neural network that classifies Alzheimer’s disease using raw OASIS 1 MRI volumes. It fuses structural T1 images with gray matter, white matter, and cerebrospinal fluid probability maps to capture complementary neuroanatomical information. Evaluated with 5‑fold subject‑level cross‑validation, the model achieves a mean accuracy of 72.34 % and an ROC AUC of 0.7781, with GradCAM visualizations highlighting anatomically relevant regions such as the medial temporal lobe and ventricles.
BrainFedFM is a structural brain MRI foundation model that was federatively pretrained on 164,707 3‑D scans from 42 sites using a dual‑priority approach that emphasizes informative anatomical regions locally and prioritizes site contributions globally. The model outperformed seven baseline models—including four centralized foundation models—across 20 downstream tasks (classification, regression, segmentation), achieving a mean rank of 1.68 and a 50% performance gain, especially in classification and regression and among underrepresented populations. These results demonstrate the model’s generalizability and show that federated pretraining can effectively develop neuroimaging foundation models without pooling raw images.