arXiv AI By Neil Chen, Adrian Serapio, Hanxue Gu, Evan Lee, Kang Wang, Yang Yang

CohortFlow: A Steerable Clinical Cohort Curation Agent with Localized Semantic Correction

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CohortFlow is a steerable agent for clinical cohort curation that applies natural language corrections as localized updates to a structured specification, allowing selective invalidation of affected computations while keeping valid results. In experiments on 100 clinical‑trial eligibility scenarios, it achieved a micro‑F1 of 77.0% versus 76.4% for full regeneration, a non‑significant difference, but reduced correction latency by 64.8% after completion and 44.3% during execution, and cut model calls by 38.1%. A proof‑of‑concept run on MIMIC showed all 13 cohort states executed successfully, with corrections preserving unaffected computations and recomputing only changed or dependent nodes.

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