arXiv AI By Mufeng Chen, Qi Wu, Bingchao Huang, Xiwen Lai, Zekai Chen, Xinge Ouyang, Quansheng Ren

CLSP-REQA: A Real-Time Quality-Aware Closed-Loop Seizure Prediction Framework with Mamba-BiLSTM and Confidence-Gated Intervention

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arXiv:2606. 00074v1 Announce Type: cross Abstract: Reliable seizure prediction is a prerequisite for closed-loop neurostimulation therapy, yet existing methods rarely account for the variability in EEG signal quality encountered in real-world deployment, and the overwhelming majority adopt non-strict evaluation protocols that overestimate generalisation performance.

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The study investigates whether Low‑Rank Adaptation (LoRA) can adapt three pretrained EEG foundation models—LaBraM‑base, REVE‑base, and REVE‑large—for binary left‑ vs. right‑hand motor imagery decoding in stroke patients. Using subject‑wise five‑fold cross‑validation on the PhysioNet EEG Motor Movement/Imagery Dataset and a binary subset of the UET175 stroke dataset, LoRA significantly improved accuracy for LaBraM‑base (0.822) and REVE‑base (0.957) on the healthy cohort, but only REVE‑base LoRA achieved high performance (0.847±0.194) on stroke data, with a best mean accuracy of 0.952 in leave‑one‑subject‑out evaluation. The results demonstrate that healthy‑benchmark performance does not guarantee transfer to stroke EEG, highlighting the need for target‑domain adaptation and subject‑level assessment in rehabilitation BCIs.

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